Simulation scenario 1, HS phase

Setting description

Treatments equally effective across the biomarker signatures

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
all	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
HRD+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
TP53+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
TEfus+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
PI3K+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
—-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
—+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
–+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
–++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
-+–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
-+-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
-++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
-+++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
+—	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
+–+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
+-+-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
+-++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
++–	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
++-+	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
+++-	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.024, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9	mean = 39, median = 31.9
++++	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 17 10 16 18 HRD+ 16 16 12 14 TP53+ 13 11 21 11 TEfus+ 19 5 13 9 PI3K+ 11 12 9 4

TC1 TC2 TC3 TC4 all 0.034 0.020 0.032 0.036 HRD+ 0.032 0.032 0.024 0.028 TP53+ 0.026 0.022 0.042 0.022 TEfus+ 0.038 0.010 0.026 0.018 PI3K+ 0.022 0.024 0.018 0.008

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 8 3 5 5 HRD+ 6 8 8 5 TP53+ 75 91 62 90 TEfus+ 41 52 52 40 PI3K+ 56 64 49 81

TC1 TC2 TC3 TC4 all 0.016 0.006 0.010 0.010 HRD+ 0.012 0.016 0.016 0.010 TP53+ 0.150 0.182 0.124 0.180 TEfus+ 0.082 0.104 0.104 0.080 PI3K+ 0.112 0.128 0.098 0.162

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.4	0.134	0.096	0.13	0.104
Error subgroup	0.4	0.134	0.096	0.13	0.104
Power signature	0.0	0.000	0.000	0.00	0.000
Power subgroup	0.0	0.000	0.000	0.00	0.000

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	17	10	16	18
all	futility	0	8	3	5	5
all	max_n	0	0	0	0	0
all	n	603 (554, 657)	288 (202, 392)	308 (208, 403)	294 (204, 394)	300 (207, 397)
all	n_unique	603 (554, 657)	288 (202, 392)	308 (208, 403)	294 (204, 394)	300 (207, 397)
all	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)
all	time_stop	NA (NA, NA)	25 (11, 52)	12 (9, 43)	15 (11, 38)	17 (11, 48)
all	post_p	NA (NA, NA)	0.48 (0.08, 0.89)	0.49 (0.09, 0.88)	0.49 (0.1, 0.89)	0.46 (0.09, 0.9)
all	rate	0.021 (0.019, 0.022)	0.022 (0.019, 0.024)	0.021 (0.019, 0.024)	0.021 (0.019, 0.024)	0.021 (0.019, 0.024)
HRD+	graduation	0	16	16	12	14
HRD+	futility	0	6	8	8	5
HRD+	max_n	0	0	0	0	0
HRD+	n	82 (68, 96)	42 (26, 62)	44 (27, 60)	47 (33, 65)	43 (26, 61)
HRD+	n_unique	82 (68, 96)	42 (26, 62)	44 (27, 60)	47 (33, 65)	43 (26, 61)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	56 (48, 59)	53 (46, 60)	50 (46, 60)	55 (50, 59)
HRD+	post_p	NA (NA, NA)	0.52 (0.11, 0.87)	0.49 (0.13, 0.87)	0.5 (0.13, 0.87)	0.52 (0.11, 0.88)
HRD+	rate	0.021 (0.017, 0.025)	0.021 (0.016, 0.03)	0.021 (0.016, 0.029)	0.022 (0.017, 0.028)	0.021 (0.016, 0.029)
TP53+	graduation	0	13	11	21	11
TP53+	futility	0	75	91	62	90
TP53+	max_n	0	0	0	0	0
TP53+	n	225 (196, 256)	110 (59, 159)	117 (62, 164)	110 (58, 161)	111 (60, 156)
TP53+	n_unique	225 (196, 256)	110 (59, 159)	117 (62, 164)	110 (58, 161)	111 (60, 156)
TP53+	time_trial	60 (60, 60)	60 (42, 60)	60 (35, 60)	60 (41, 60)	60 (39, 60)
TP53+	time_stop	NA (NA, NA)	39 (27, 55)	36 (21, 51)	38 (26, 52)	39 (27, 54)
TP53+	post_p	NA (NA, NA)	0.47 (0.11, 0.87)	0.47 (0.09, 0.9)	0.53 (0.11, 0.92)	0.49 (0.1, 0.9)
TP53+	rate	0.021 (0.018, 0.023)	0.021 (0.018, 0.026)	0.022 (0.018, 0.027)	0.021 (0.017, 0.026)	0.021 (0.018, 0.026)
TEfus+	graduation	0	19	5	13	9
TEfus+	futility	0	41	52	52	40
TEfus+	max_n	0	0	0	0	0
TEfus+	n	192 (170, 217)	97 (58, 134)	100 (58, 139)	97 (58, 136)	97 (60, 139)
TEfus+	n_unique	192 (170, 217)	97 (58, 134)	100 (58, 139)	97 (58, 136)	97 (60, 139)
TEfus+	time_trial	60 (60, 60)	60 (54, 60)	60 (57, 60)	60 (48, 60)	60 (60, 60)
TEfus+	time_stop	NA (NA, NA)	42 (29, 57)	42 (25, 58)	40 (29, 54)	44 (31, 56)
TEfus+	post_p	NA (NA, NA)	0.48 (0.09, 0.87)	0.46 (0.09, 0.88)	0.49 (0.11, 0.89)	0.49 (0.1, 0.89)
TEfus+	rate	0.021 (0.018, 0.024)	0.021 (0.017, 0.026)	0.022 (0.018, 0.027)	0.021 (0.018, 0.026)	0.021 (0.018, 0.026)
PI3K+	graduation	0	11	12	9	4
PI3K+	futility	0	56	64	49	81
PI3K+	max_n	0	0	0	0	0
PI3K+	n	208 (183, 236)	104 (60, 145)	108 (59, 148)	106 (59, 146)	108 (60, 154)
PI3K+	n_unique	208 (183, 236)	104 (60, 145)	108 (59, 148)	106 (59, 146)	108 (60, 154)
PI3K+	time_trial	60 (60, 60)	60 (51, 60)	60 (47, 60)	60 (52, 60)	60 (38, 60)
PI3K+	time_stop	NA (NA, NA)	42 (28, 56)	44 (28, 54)	37 (30, 53)	36 (24, 51)
PI3K+	post_p	NA (NA, NA)	0.46 (0.07, 0.88)	0.45 (0.08, 0.87)	0.51 (0.1, 0.87)	0.49 (0.07, 0.87)
PI3K+	rate	0.02 (0.018, 0.023)	0.021 (0.018, 0.026)	0.022 (0.018, 0.026)	0.021 (0.017, 0.026)	0.022 (0.018, 0.027)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	17	10	16	18
—-	futility	0	8	3	5	5
—-	max_n	0	0	0	0	0
—-	n	188 (156, 222)	73 (30, 160)	88 (29, 166)	71 (23, 157)	85 (25, 163)
—-	n_unique	188 (156, 222)	73 (30, 160)	88 (29, 166)	71 (23, 157)	85 (25, 163)
—-	post_p	NA (NA, NA)	0.42 (0.09, 0.87)	0.5 (0.08, 0.88)	0.43 (0.07, 0.86)	0.45 (0.08, 0.87)
—-	rate	0.021 (0.018, 0.024)	0.022 (0.018, 0.029)	0.022 (0.017, 0.029)	0.022 (0.017, 0.03)	0.021 (0.017, 0.029)
—+	graduation	0	26	21	25	22
—+	futility	0	57	65	49	82
—+	max_n	0	0	0	0	0
—+	n	42 (31, 54)	21 (10, 39)	18 (8, 38)	20 (7, 39)	19 (9, 39)
—+	n_unique	42 (31, 54)	21 (10, 39)	18 (8, 38)	20 (7, 39)	19 (9, 39)
—+	post_p	NA (NA, NA)	0.49 (0.14, 0.85)	0.43 (0.13, 0.85)	0.49 (0.11, 0.86)	0.47 (0.13, 0.83)
—+	rate	0.021 (0.015, 0.028)	0.022 (0.015, 0.034)	0.023 (0.015, 0.038)	0.021 (0.014, 0.036)	0.022 (0.015, 0.035)
–+-	graduation	0	33	14	29	27
–+-	futility	0	43	53	52	43
–+-	max_n	0	0	0	0	0
–+-	n	12 (7, 17)	6 (3, 12)	8 (4, 14)	6 (3, 11)	6 (3, 12)
–+-	n_unique	12 (7, 17)	6 (3, 12)	8 (4, 14)	6 (3, 11)	6 (3, 12)
–+-	post_p	NA (NA, NA)	0.49 (0.2, 0.8)	0.47 (0.2, 0.79)	0.47 (0.21, 0.8)	0.51 (0.22, 0.75)
–+-	rate	0.021 (0.011, 0.035)	0.023 (0.009, 0.048)	0.022 (0.01, 0.043)	0.023 (0.008, 0.048)	0.021 (0.009, 0.047)
–++	graduation	0	41	24	36	29
–++	futility	0	86	99	83	107
–++	max_n	0	0	0	0	0
–++	n	62 (50, 77)	27 (11, 56)	28 (11, 58)	26 (11, 57)	28 (12, 58)
–++	n_unique	62 (50, 77)	27 (11, 56)	28 (11, 58)	26 (11, 57)	28 (12, 58)
–++	post_p	NA (NA, NA)	0.44 (0.11, 0.83)	0.46 (0.11, 0.86)	0.47 (0.14, 0.86)	0.46 (0.11, 0.86)
–++	rate	0.02 (0.016, 0.026)	0.022 (0.016, 0.035)	0.022 (0.015, 0.034)	0.022 (0.015, 0.033)	0.022 (0.016, 0.034)
-+–	graduation	0	27	20	37	27
-+–	futility	0	76	92	63	91
-+–	max_n	0	0	0	0	0
-+–	n	78 (63, 97)	35 (14, 68)	34 (15, 72)	34 (13, 68)	34 (13, 64)
-+–	n_unique	78 (63, 97)	35 (14, 68)	34 (15, 72)	34 (13, 68)	34 (13, 64)
-+–	post_p	NA (NA, NA)	0.48 (0.11, 0.85)	0.49 (0.12, 0.87)	0.5 (0.13, 0.86)	0.48 (0.11, 0.86)
-+–	rate	0.021 (0.017, 0.025)	0.022 (0.016, 0.032)	0.022 (0.017, 0.033)	0.021 (0.016, 0.031)	0.022 (0.016, 0.033)
-+-+	graduation	0	35	29	46	30
-+-+	futility	0	106	127	92	138
-+-+	max_n	0	0	0	0	0
-+-+	n	52 (42, 65)	21 (9, 49)	24 (10, 50)	23 (9, 47)	23 (10, 47)
-+-+	n_unique	52 (42, 65)	21 (9, 49)	24 (10, 50)	23 (9, 47)	23 (10, 47)
-+-+	post_p	NA (NA, NA)	0.46 (0.11, 0.86)	0.48 (0.13, 0.86)	0.49 (0.11, 0.89)	0.46 (0.11, 0.86)
-+-+	rate	0.02 (0.015, 0.026)	0.022 (0.015, 0.038)	0.022 (0.015, 0.034)	0.021 (0.014, 0.035)	0.023 (0.016, 0.034)
-++-	graduation	0	42	24	46	34
-++-	futility	0	104	130	100	114
-++-	max_n	0	0	0	0	0
-++-	n	48 (36, 59)	22 (8, 42)	21 (10, 44)	19 (8, 41)	20 (8, 42)
-++-	n_unique	48 (36, 59)	22 (8, 42)	21 (10, 44)	19 (8, 41)	20 (8, 42)
-++-	post_p	NA (NA, NA)	0.5 (0.16, 0.86)	0.46 (0.13, 0.85)	0.5 (0.14, 0.87)	0.51 (0.13, 0.87)
-++-	rate	0.021 (0.016, 0.028)	0.022 (0.015, 0.035)	0.023 (0.016, 0.035)	0.022 (0.014, 0.034)	0.022 (0.014, 0.038)
-+++	graduation	0	49	32	53	36
-+++	futility	0	133	156	121	156
-+++	max_n	0	0	0	0	0
-+++	n	37 (27, 47)	15 (6, 32)	16 (7, 34)	16 (6, 34)	16 (8, 36)
-+++	n_unique	37 (27, 47)	15 (6, 32)	16 (7, 34)	16 (6, 34)	16 (8, 36)
-+++	post_p	NA (NA, NA)	0.47 (0.13, 0.84)	0.44 (0.12, 0.84)	0.49 (0.15, 0.86)	0.45 (0.15, 0.85)
-+++	rate	0.02 (0.014, 0.027)	0.022 (0.013, 0.04)	0.023 (0.014, 0.039)	0.022 (0.013, 0.038)	0.022 (0.014, 0.034)
+—	graduation	0	33	26	28	32
+—	futility	0	14	11	13	10
+—	max_n	0	0	0	0	0
+—	n	39 (30, 50)	18 (7, 34)	20 (9, 35)	21 (10, 36)	18 (8, 32)
+—	n_unique	39 (30, 50)	18 (7, 34)	20 (9, 35)	21 (10, 36)	18 (8, 32)
+—	post_p	NA (NA, NA)	0.49 (0.13, 0.85)	0.5 (0.13, 0.86)	0.5 (0.15, 0.84)	0.48 (0.16, 0.84)
+—	rate	0.021 (0.016, 0.029)	0.022 (0.014, 0.038)	0.022 (0.014, 0.034)	0.022 (0.015, 0.033)	0.022 (0.014, 0.036)
+–+	graduation	0	42	37	34	36
+–+	futility	0	63	69	55	87
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+–+	rate	0.047 (0.047, 0.047)	0 (0, 0)	0.029 (0, 0.34)	0 (0, 0.058)	0.058 (0.058, 0.058)
+-+-	graduation	0	49	29	40	39
+-+-	futility	0	47	58	59	48
+-+-	max_n	0	0	0	0	0
+-+-	n	27 (20, 36)	13 (6, 25)	13 (6, 24)	15 (7, 25)	13 (6, 24)
+-+-	n_unique	27 (20, 36)	13 (6, 25)	13 (6, 24)	15 (7, 25)	13 (6, 24)
+-+-	post_p	NA (NA, NA)	0.5 (0.18, 0.84)	0.48 (0.17, 0.84)	0.47 (0.15, 0.86)	0.5 (0.15, 0.82)
+-+-	rate	0.021 (0.014, 0.03)	0.022 (0.012, 0.038)	0.022 (0.012, 0.04)	0.022 (0.014, 0.036)	0.022 (0.013, 0.039)
+-++	graduation	0	57	39	46	41
+-++	futility	0	90	102	88	112
+-++	max_n	0	0	0	0	0
+-++	n	6 (3, 10)	3 (1, 7)	3 (1, 7)	4 (1, 7)	4 (1, 7)
+-++	n_unique	6 (3, 10)	3 (1, 7)	3 (1, 7)	4 (1, 7)	4 (1, 7)
+-++	post_p	NA (NA, NA)	0.5 (0.29, 0.69)	0.49 (0.3, 0.68)	0.48 (0.32, 0.67)	0.48 (0.31, 0.69)
+-++	rate	0.021 (0.004, 0.042)	0.021 (0, 0.068)	0.022 (0, 0.069)	0.021 (0, 0.064)	0.023 (0, 0.059)
++–	graduation	0	43	35	49	41
++–	futility	0	80	95	68	94
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
++–	n_unique	1 (0, 3)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)
++–	post_p	NA (NA, NA)	0.5 (0.43, 0.57)	0.5 (0.43, 0.57)	0.5 (0.43, 0.57)	0.5 (0.44, 0.58)
++–	rate	0.016 (0, 0.107)	0.019 (0, 0.11)	0.017 (0, 0.096)	0.02 (0, 0.105)	0.016 (0, 0.096)
++-+	graduation	0	51	44	55	44
++-+	futility	0	110	128	95	141
++-+	max_n	0	0	0	0	0
++-+	n	8 (4, 12)	4 (1, 9)	4 (1, 9)	5 (2, 9)	5 (2, 9)
++-+	n_unique	8 (4, 12)	4 (1, 9)	4 (1, 9)	5 (2, 9)	5 (2, 9)
++-+	post_p	NA (NA, NA)	0.49 (0.28, 0.73)	0.49 (0.29, 0.74)	0.47 (0.28, 0.72)	0.48 (0.27, 0.73)
++-+	rate	0.02 (0.007, 0.037)	0.022 (0, 0.055)	0.021 (0.006, 0.061)	0.023 (0.008, 0.062)	0.022 (0.008, 0.057)
+++-	graduation	0	58	38	57	46
+++-	futility	0	106	133	104	117
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.44 (0.44, 0.44)
+++-	rate	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.021)	0.05 (0.01, 0.059)
++++	graduation	0	65	46	63	48
++++	futility	0	135	157	123	159
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	0.45 (0.45, 0.45)	0.51 (0.5, 0.52)	0.51 (0.43, 0.51)	0.5 (0.5, 0.5)
++++	rate	0 (0, 0.023)	0.035 (0, 0.059)	0.028 (0, 0.384)	0.045 (0, 0.251)	0 (0, 0.106)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	17	10	16	18
all	time_stop	16 (10, 39)	11 (9, 37)	14 (10, 17)	16 (11, 33)
all	n_trt	97 (67, 244)	66 (58, 225)	66 (52, 99)	74 (60, 186)
all	n_control	136 (79, 374)	92 (75, 319)	118 (82, 141)	124 (93, 285)
all	post_p	0.94 (0.87, 0.99)	0.92 (0.9, 0.93)	0.92 (0.87, 0.96)	0.95 (0.89, 0.98)
all	order	1 (1, 2)	1 (1, 1.1)	1 (1, 1)	1 (1, 1.3)
HRD+	count	16	16	12	14
HRD+	time_stop	52 (48, 58)	50 (45, 60)	49 (44, 60)	56 (50, 59)
HRD+	n_trt	52 (50, 60)	52 (50, 54)	52 (50, 58)	54 (50, 61)
HRD+	n_control	68 (57, 76)	64 (43, 80)	64 (49, 79)	68 (59, 83)
HRD+	post_p	0.92 (0.86, 0.98)	0.97 (0.87, 0.99)	0.94 (0.87, 0.99)	0.95 (0.9, 0.96)
HRD+	order	1 (1, 3)	1 (1, 2)	1 (1, 2)	1 (1, 2)
TP53+	count	13	11	21	11
TP53+	time_stop	28 (20, 40)	44 (32, 51)	29 (23, 52)	37 (21, 52)
TP53+	n_trt	59 (51, 75)	122 (72, 135)	62 (52, 98)	88 (52, 110)
TP53+	n_control	74 (62, 119)	136 (113, 167)	91 (67, 170)	124 (64, 169)
TP53+	post_p	0.95 (0.88, 0.99)	0.98 (0.94, 0.99)	0.95 (0.88, 0.98)	0.97 (0.91, 1)
TP53+	order	1 (1, 1)	1 (1, 2)	1 (1, 2)	1 (1, 2)
TEfus+	count	19	5	13	9
TEfus+	time_stop	31 (26, 48)	29 (20, 49)	32 (27, 48)	32 (29, 53)
TEfus+	n_trt	66 (51, 96)	60 (52, 103)	62 (54, 99)	60 (54, 102)
TEfus+	n_control	87 (64, 136)	77 (53, 148)	88 (67, 121)	87 (72, 145)
TEfus+	post_p	0.95 (0.89, 0.99)	0.95 (0.9, 0.99)	0.98 (0.9, 1)	0.95 (0.92, 0.99)
TEfus+	order	1 (1, 2)	1 (1, 2.2)	1 (1, 3)	1 (1, 2)
PI3K+	count	11	12	9	4
PI3K+	time_stop	31 (25, 48)	38 (30, 52)	30 (26, 48)	34 (22, 42)
PI3K+	n_trt	70 (52, 96)	78 (57, 92)	60 (51, 132)	92 (65, 116)
PI3K+	n_control	92 (67, 166)	116 (95, 151)	90 (75, 145)	94 (65, 123)
PI3K+	post_p	0.98 (0.93, 0.99)	0.98 (0.96, 0.99)	0.96 (0.93, 0.99)	0.98 (0.93, 0.99)
PI3K+	order	1 (1, 2)	1 (1, 2.9)	1 (1, 2)	1 (1, 1)

Futility:

signature	var	TC1	TC2	TC3	TC4
all	count	8	3	5	5
all	time_stop	48 (31, 53)	43 (24, 46)	38 (36, 52)	48 (29, 49)
all	n_trt	158 (145, 177)	163 (105, 165)	181 (131, 211)	185 (131, 229)
all	n_control	462 (289, 509)	407 (213, 468)	362 (343, 489)	480 (262, 559)
all	post_p	0.01 (0, 0.04)	0.01 (0, 0.02)	0.02 (0.01, 0.16)	0.02 (0.01, 0.14)
all	order	3 (1, 5.3)	2 (1.2, 2)	4 (3, 4)	4 (1.4, 5.6)
HRD+	count	6	8	8	5
HRD+	time_stop	58 (54, 60)	56 (51, 60)	52 (47, 58)	55 (50, 59)
HRD+	n_trt	50 (50, 58)	54 (51, 64)	52 (50, 56)	52 (50, 66)
HRD+	n_control	78 (62, 88)	80 (68, 95)	65 (54, 78)	79 (61, 93)
HRD+	post_p	0.19 (0.07, 0.23)	0.16 (0.11, 0.23)	0.16 (0.11, 0.25)	0.12 (0.07, 0.29)
HRD+	order	2 (1, 2.5)	3 (2, 5.2)	3 (1.7, 4.6)	3 (1.4, 4.2)
TP53+	count	75	91	62	90
TP53+	time_stop	40 (28, 56)	33 (21, 50)	40 (30, 52)	39 (28, 54)
TP53+	n_trt	67 (52, 105)	64 (51, 101)	64 (51, 101)	74 (52, 104)
TP53+	n_control	138 (90, 204)	108 (68, 181)	138 (91, 186)	139 (86, 194)
TP53+	post_p	0.09 (0.01, 0.22)	0.12 (0.03, 0.24)	0.12 (0.03, 0.22)	0.11 (0.03, 0.21)
TP53+	order	1 (1, 3)	1 (1, 2)	1 (1, 3)	2 (1, 3)
TEfus+	count	41	52	52	40
TEfus+	time_stop	47 (34, 58)	43 (28, 59)	42 (31, 55)	46 (36, 56)
TEfus+	n_trt	66 (52, 117)	62 (50, 94)	60 (50, 86)	66 (54, 83)
TEfus+	n_control	141 (91, 194)	129 (65, 181)	125 (82, 175)	144 (103, 173)
TEfus+	post_p	0.1 (0.02, 0.24)	0.11 (0.02, 0.23)	0.11 (0.03, 0.22)	0.06 (0.01, 0.19)
TEfus+	order	2 (1, 4)	2 (1, 3)	2 (1, 3)	2 (1, 4)
PI3K+	count	56	64	49	81
PI3K+	time_stop	43 (28, 58)	45 (27, 55)	39 (31, 54)	36 (25, 51)
PI3K+	n_trt	62 (50, 100)	63 (50, 103)	61 (50, 107)	68 (53, 99)
PI3K+	n_control	134 (80, 202)	144 (76, 201)	127 (84, 188)	114 (67, 176)
PI3K+	post_p	0.1 (0.02, 0.21)	0.07 (0.03, 0.21)	0.06 (0.02, 0.2)	0.09 (0.02, 0.22)
PI3K+	order	2 (1, 4)	2 (1, 4)	2 (1, 3.2)	1 (1, 3)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17	17
all	TC1	time	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)	16 (10, 39)
all	TC1	n	37 (25, 77)	9 (5, 16)	2 (0, 5)	10 (4, 28)	14 (7, 22)	7 (3, 25)	8 (4, 17)	4 (2, 10)	6 (1, 18)	0 (0, 0)	4 (1, 11)	1 (0, 4)	0 (0, 0)	1 (0, 5)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.61 (0.54, 0.74)	0.57 (0.55, 0.77)	0.53 (0.5, 0.55)	0.55 (0.52, 0.8)	0.57 (0.51, 0.75)	0.59 (0.51, 0.78)	0.54 (0.51, 0.85)	0.54 (0.5, 0.64)	0.53 (0.51, 0.72)	NA (NA, NA)	0.54 (0.51, 0.66)	0.54 (0.51, 0.55)	NA (NA, NA)	0.54 (0.52, 0.73)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.012 (0.004, 0.017)	0 (0, 0.015)	0 (0, 0.009)	0 (0, 0.016)	0 (0, 0.021)	0 (0, 0.015)	0 (0, 0.021)	0 (0, 0.013)	0 (0, 0.021)	NA (NA, NA)	0 (0, 0.013)	0 (0, 0.01)	0 (0, 0)	0 (0, 0.016)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10	10
all	TC2	time	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)	11 (9, 37)
all	TC2	n	28 (17, 71)	4 (1, 15)	4 (2, 6)	6 (2, 22)	12 (8, 34)	8 (5, 21)	8 (6, 25)	4 (2, 12)	4 (0, 12)	0 (0, 0)	1 (0, 8)	0 (0, 1)	0 (0, 0)	1 (0, 4)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.57 (0.52, 0.69)	0.55 (0.51, 0.69)	0.54 (0.51, 0.65)	0.55 (0.52, 0.8)	0.58 (0.53, 0.68)	0.54 (0.51, 0.8)	0.55 (0.52, 0.78)	0.53 (0.52, 0.56)	0.54 (0.52, 0.56)	NA (NA, NA)	0.54 (0.52, 0.76)	0.56 (0.51, 0.6)	NA (NA, NA)	0.52 (0.5, 0.59)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.011 (0, 0.02)	0 (0, 0.012)	0 (0, 0.014)	0 (0, 0.015)	0.008 (0, 0.019)	0 (0, 0.015)	0 (0, 0.015)	0 (0, 0.014)	0.007 (0, 0.027)	NA (NA, NA)	0 (0, 0.012)	0 (0, 0)	0 (0, 0)	0 (0, 0.018)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16	16
all	TC3	time	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)	14 (10, 17)
all	TC3	n	17 (11, 33)	4 (1, 8)	1 (0, 2)	6 (3, 11)	7 (4, 12)	6 (2, 10)	4 (1, 10)	3 (2, 8)	7 (6, 12)	0 (0, 0)	7 (4, 10)	1 (0, 2)	0 (0, 1)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.57 (0.52, 0.77)	0.54 (0.51, 0.62)	0.52 (0.5, 0.55)	0.53 (0.5, 0.61)	0.53 (0.52, 0.58)	0.53 (0.51, 0.63)	0.52 (0.5, 0.59)	0.54 (0.51, 0.57)	0.54 (0.5, 0.6)	NA (NA, NA)	0.55 (0.52, 0.62)	0.52 (0.51, 0.53)	0.52 (0.52, 0.52)	0.52 (0.51, 0.54)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.005 (0, 0.017)	0 (0, 0.015)	0 (0, 0.023)	0 (0, 0.007)	0 (0, 0.016)	0 (0, 0.009)	0 (0, 0.009)	0 (0, 0.008)	0 (0, 0.015)	NA (NA, NA)	0 (0, 0)	0 (0, 0.11)	0 (0, 0)	0 (0, 0.061)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	18	18	18	18	18	18	18	18	18	18	18	18	18	18	18	18
all	TC4	time	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)	16 (11, 33)
all	TC4	n	22 (13, 77)	8 (2, 14)	2 (1, 4)	10 (5, 16)	10 (4, 18)	8 (5, 15)	5 (2, 18)	7 (3, 16)	4 (2, 14)	0 (0, 0)	3 (1, 7)	1 (0, 3)	0 (0, 1)	2 (0, 4)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.7 (0.56, 0.81)	0.55 (0.5, 0.6)	0.53 (0.51, 0.59)	0.57 (0.52, 0.63)	0.56 (0.51, 0.78)	0.57 (0.51, 0.66)	0.55 (0.51, 0.63)	0.55 (0.52, 0.65)	0.55 (0.52, 0.8)	NA (NA, NA)	0.54 (0.5, 0.58)	0.53 (0.5, 0.55)	0.52 (0.52, 0.52)	0.52 (0.51, 0.56)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.006 (0, 0.017)	0 (0, 0.017)	0 (0, 0.006)	0 (0, 0.018)	0 (0, 0.018)	0.003 (0, 0.016)	0 (0, 0.018)	0 (0, 0.015)	0 (0, 0.012)	NA (NA, NA)	0 (0, 0.011)	0 (0, 0.042)	0 (0, 19.453)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									16	16	16	16	16	16	16	16
HRD+	TC1	time									52 (48, 58)	52 (48, 58)	52 (48, 58)	52 (48, 58)	52 (48, 58)	52 (48, 58)	52 (48, 58)	52 (48, 58)
HRD+	TC1	n									28 (19, 36)	0 (0, 0)	16 (10, 27)	4 (2, 6)	0 (0, 1)	6 (2, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.79 (0.74, 0.94)	NA (NA, NA)	0.76 (0.64, 0.91)	0.58 (0.51, 0.61)	0.51 (0.5, 0.52)	0.54 (0.51, 0.64)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.013 (0.009, 0.02)	NA (NA, NA)	0.014 (0.007, 0.02)	0.013 (0, 0.024)	0 (0, 0.027)	0.011 (0, 0.023)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									16	16	16	16	16	16	16	16
HRD+	TC2	time									50 (45, 60)	50 (45, 60)	50 (45, 60)	50 (45, 60)	50 (45, 60)	50 (45, 60)	50 (45, 60)	50 (45, 60)
HRD+	TC2	n									28 (21, 34)	0 (0, 0)	15 (10, 23)	4 (1, 6)	0 (0, 2)	5 (3, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.86 (0.71, 0.95)	NA (NA, NA)	0.78 (0.65, 0.95)	0.57 (0.53, 0.65)	0.56 (0.56, 0.56)	0.58 (0.52, 0.85)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.013 (0.008, 0.018)	NA (NA, NA)	0.011 (0.005, 0.018)	0 (0, 0.014)	0 (0, 0.102)	0.014 (0.007, 0.023)	NA (NA, NA)	0 (0, 0)
HRD+	TC3	count									12	12	12	12	12	12	12	12
HRD+	TC3	time									49 (44, 60)	49 (44, 60)	49 (44, 60)	49 (44, 60)	49 (44, 60)	49 (44, 60)	49 (44, 60)	49 (44, 60)
HRD+	TC3	n									26 (18, 33)	0 (0, 0)	18 (9, 21)	4 (3, 8)	0 (0, 2)	5 (2, 10)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.8 (0.71, 0.89)	NA (NA, NA)	0.76 (0.6, 0.89)	0.56 (0.52, 0.77)	0.58 (0.53, 0.61)	0.6 (0.52, 0.72)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.015 (0.013, 0.018)	0 (0, 0)	0.018 (0.009, 0.022)	0.009 (0, 0.017)	0.008 (0, 0.039)	0.011 (0, 0.023)	NA (NA, NA)	0 (0, 0)
HRD+	TC4	count									14	14	14	14	14	14	14	14
HRD+	TC4	time									56 (50, 59)	56 (50, 59)	56 (50, 59)	56 (50, 59)	56 (50, 59)	56 (50, 59)	56 (50, 59)	56 (50, 59)
HRD+	TC4	n									22 (16, 34)	0 (0, 0)	19 (15, 25)	5 (2, 9)	1 (0, 2)	5 (3, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.77 (0.71, 0.8)	NA (NA, NA)	0.77 (0.7, 0.96)	0.58 (0.53, 0.74)	0.52 (0.51, 0.57)	0.6 (0.56, 0.72)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.015 (0.012, 0.02)	NA (NA, NA)	0.015 (0.009, 0.021)	0.01 (0, 0.019)	0 (0, 0.063)	0.014 (0, 0.021)	NA (NA, NA)	0 (0, 0)
TP53+	TC1	count					13	13	13	13					13	13	13	13
TP53+	TC1	time					28 (20, 40)	28 (20, 40)	28 (20, 40)	28 (20, 40)					28 (20, 40)	28 (20, 40)	28 (20, 40)	28 (20, 40)
TP53+	TC1	n					25 (21, 34)	13 (8, 20)	9 (7, 16)	9 (4, 19)					0 (0, 1)	1 (0, 4)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.82 (0.72, 0.89)	0.72 (0.53, 0.81)	0.63 (0.51, 0.73)	0.57 (0.54, 0.82)					NA (NA, NA)	0.52 (0.51, 0.62)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.009 (0, 0.014)	0.009 (0.001, 0.017)	0.01 (0, 0.02)	0.006 (0, 0.011)					0 (0, 0.122)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					11	11	11	11					11	11	11	11
TP53+	TC2	time					44 (32, 51)	44 (32, 51)	44 (32, 51)	44 (32, 51)					44 (32, 51)	44 (32, 51)	44 (32, 51)	44 (32, 51)
TP53+	TC2	n					47 (28, 69)	18 (14, 28)	24 (16, 36)	15 (8, 24)					1 (0, 2)	3 (1, 4)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.83 (0.73, 0.91)	0.79 (0.7, 0.86)	0.77 (0.71, 0.92)	0.76 (0.6, 0.84)					0.54 (0.53, 0.58)	0.52 (0.5, 0.59)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.014 (0.01, 0.02)	0.013 (0.004, 0.021)	0.013 (0.01, 0.016)	0.013 (0.004, 0.016)					0 (0, 0.071)	0.016 (0, 0.058)	NA (NA, NA)	0.023 (0.023, 0.023)
TP53+	TC3	count					21	21	21	21					21	21	21	21
TP53+	TC3	time					29 (23, 52)	29 (23, 52)	29 (23, 52)	29 (23, 52)					29 (23, 52)	29 (23, 52)	29 (23, 52)	29 (23, 52)
TP53+	TC3	n					23 (16, 34)	15 (10, 27)	12 (7, 27)	7 (5, 11)					0 (0, 2)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.75 (0.71, 0.86)	0.74 (0.57, 0.87)	0.71 (0.54, 0.82)	0.6 (0.51, 0.79)					0.55 (0.53, 0.56)	0.54 (0.51, 0.59)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.012 (0.005, 0.018)	0.012 (0, 0.018)	0.009 (0, 0.018)	0.014 (0, 0.022)					0 (0, 0.119)	0 (0, 0.027)	NA (NA, NA)	0 (0, 0)
TP53+	TC4	count					11	11	11	11					11	11	11	11
TP53+	TC4	time					37 (21, 52)	37 (21, 52)	37 (21, 52)	37 (21, 52)					37 (21, 52)	37 (21, 52)	37 (21, 52)	37 (21, 52)
TP53+	TC4	n					30 (13, 38)	23 (16, 27)	13 (7, 27)	14 (9, 22)					0 (0, 1)	3 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.79 (0.7, 0.9)	0.76 (0.71, 0.83)	0.75 (0.55, 0.92)	0.75 (0.54, 0.94)					0.51 (0.51, 0.51)	0.54 (0.52, 0.61)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.013 (0.007, 0.015)	0.011 (0.007, 0.015)	0.014 (0, 0.016)	0.014 (0.009, 0.017)					0 (0, 0.126)	0 (0, 0.026)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			19	19			19	19			19	19			19	19
TEfus+	TC1	time			31 (26, 48)	31 (26, 48)			31 (26, 48)	31 (26, 48)			31 (26, 48)	31 (26, 48)			31 (26, 48)	31 (26, 48)
TEfus+	TC1	n			4 (1, 6)	21 (19, 40)			15 (9, 25)	10 (5, 20)			8 (6, 11)	2 (1, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.55 (0.51, 0.68)	0.77 (0.72, 0.95)			0.75 (0.54, 0.89)	0.66 (0.51, 0.76)			0.61 (0.52, 0.71)	0.55 (0.52, 0.63)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.005 (0, 0.019)	0.009 (0.005, 0.014)			0.009 (0.004, 0.02)	0.011 (0.007, 0.019)			0.009 (0, 0.023)	0 (0, 0.02)			NA (NA, NA)	0 (0, 0)
TEfus+	TC2	count			5	5			5	5			5	5			5	5
TEfus+	TC2	time			29 (20, 49)	29 (20, 49)			29 (20, 49)	29 (20, 49)			29 (20, 49)	29 (20, 49)			29 (20, 49)	29 (20, 49)
TEfus+	TC2	n			4 (1, 9)	21 (20, 41)			18 (13, 26)	8 (8, 15)			10 (6, 11)	1 (0, 4)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.54 (0.52, 0.61)	0.83 (0.79, 0.93)			0.72 (0.71, 0.75)	0.57 (0.51, 0.72)			0.55 (0.53, 0.67)	0.72 (0.55, 0.9)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.013 (0, 0.015)	0.009 (0.004, 0.02)			0.01 (0.006, 0.015)	0.011 (0.004, 0.021)			0.016 (0.009, 0.022)	0 (0, 0.005)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	count			13	13			13	13			13	13			13	13
TEfus+	TC3	time			32 (27, 48)	32 (27, 48)			32 (27, 48)	32 (27, 48)			32 (27, 48)	32 (27, 48)			32 (27, 48)	32 (27, 48)
TEfus+	TC3	n			5 (1, 8)	20 (17, 33)			12 (8, 20)	10 (7, 16)			10 (7, 17)	3 (1, 7)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.57 (0.52, 0.63)	0.78 (0.72, 0.89)			0.81 (0.53, 0.89)	0.69 (0.52, 0.76)			0.63 (0.52, 0.81)	0.54 (0.51, 0.58)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0 (0, 0.015)	0.009 (0.001, 0.018)			0.008 (0.001, 0.018)	0.011 (0, 0.018)			0.016 (0.007, 0.025)	0 (0, 0.015)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			9	9			9	9			9	9			9	9
TEfus+	TC4	time			32 (29, 53)	32 (29, 53)			32 (29, 53)	32 (29, 53)			32 (29, 53)	32 (29, 53)			32 (29, 53)	32 (29, 53)
TEfus+	TC4	n			4 (2, 10)	20 (19, 31)			19 (7, 27)	13 (8, 18)			8 (3, 17)	2 (1, 7)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.57 (0.53, 0.79)	0.74 (0.72, 0.79)			0.74 (0.64, 0.89)	0.71 (0.53, 0.77)			0.62 (0.54, 0.83)	0.53 (0.51, 0.67)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0 (0, 0.013)	0.012 (0.006, 0.014)			0.01 (0.005, 0.014)	0.014 (0.012, 0.017)			0.01 (0, 0.019)	0.015 (0, 0.061)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		11		11		11		11		11		11		11		11
PI3K+	TC1	time		31 (25, 48)		31 (25, 48)		31 (25, 48)		31 (25, 48)		31 (25, 48)		31 (25, 48)		31 (25, 48)		31 (25, 48)
PI3K+	TC1	n		18 (9, 21)		22 (16, 47)		14 (9, 28)		7 (4, 12)		0 (0, 0)		3 (1, 5)		2 (0, 5)		0 (0, 0)
PI3K+	TC1	post_p		0.77 (0.65, 0.82)		0.8 (0.73, 0.92)		0.72 (0.59, 0.82)		0.6 (0.52, 0.73)		NA (NA, NA)		0.53 (0.51, 0.66)		0.56 (0.5, 0.69)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.01 (0, 0.018)		0.011 (0, 0.017)		0.012 (0.005, 0.016)		0.013 (0.007, 0.023)		NA (NA, NA)		0 (0, 0.033)		0 (0, 0.016)		NA (NA, NA)
PI3K+	TC2	count		12		12		12		12		12		12		12		12
PI3K+	TC2	time		38 (30, 52)		38 (30, 52)		38 (30, 52)		38 (30, 52)		38 (30, 52)		38 (30, 52)		38 (30, 52)		38 (30, 52)
PI3K+	TC2	n		14 (6, 27)		24 (17, 36)		17 (10, 28)		10 (6, 20)		0 (0, 0)		2 (0, 3)		2 (1, 5)		0 (0, 0)
PI3K+	TC2	post_p		0.72 (0.55, 0.8)		0.8 (0.74, 0.95)		0.76 (0.65, 0.85)		0.64 (0.55, 0.75)		NA (NA, NA)		0.54 (0.5, 0.57)		0.54 (0.51, 0.7)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.012 (0, 0.016)		0.013 (0.008, 0.022)		0.011 (0.008, 0.016)		0.013 (0.009, 0.017)		NA (NA, NA)		0 (0, 0.028)		0 (0, 0.014)		NA (NA, NA)
PI3K+	TC3	count		9		9		9		9		9		9		9		9
PI3K+	TC3	time		30 (26, 48)		30 (26, 48)		30 (26, 48)		30 (26, 48)		30 (26, 48)		30 (26, 48)		30 (26, 48)		30 (26, 48)
PI3K+	TC3	n		11 (8, 21)		18 (9, 41)		17 (14, 30)		13 (9, 26)		0 (0, 0)		2 (0, 3)		4 (1, 7)		0 (0, 0)
PI3K+	TC3	post_p		0.79 (0.53, 0.88)		0.76 (0.57, 0.84)		0.72 (0.67, 0.79)		0.78 (0.54, 0.93)		NA (NA, NA)		0.52 (0.51, 0.53)		0.56 (0.51, 0.59)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.006 (0, 0.018)		0.013 (0, 0.019)		0.011 (0.007, 0.022)		0.012 (0.004, 0.016)		NA (NA, NA)		0 (0, 0.018)		0 (0, 0.014)		NA (NA, NA)
PI3K+	TC4	count		4		4		4		4		4		4		4		4
PI3K+	TC4	time		34 (22, 42)		34 (22, 42)		34 (22, 42)		34 (22, 42)		34 (22, 42)		34 (22, 42)		34 (22, 42)		34 (22, 42)
PI3K+	TC4	n		13 (10, 20)		32 (28, 46)		30 (17, 37)		7 (6, 13)		0 (0, 0)		2 (1, 3)		2 (1, 4)		0 (0, 0)
PI3K+	TC4	post_p		0.7 (0.56, 0.87)		0.81 (0.8, 0.83)		0.74 (0.71, 0.75)		0.63 (0.51, 0.76)		NA (NA, NA)		0.52 (0.51, 0.57)		0.53 (0.52, 0.55)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.013 (0.01, 0.015)		0.011 (0.008, 0.016)		0.008 (0.007, 0.013)		0.013 (0.003, 0.024)		NA (NA, NA)		0 (0, 0.009)		0 (0, 0.014)		NA (NA, NA)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8	8
all	TC1	time	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)	48 (31, 53)
all	TC1	n	44 (36, 56)	11 (7, 18)	5 (4, 7)	11 (9, 22)	13 (10, 25)	14 (8, 24)	12 (7, 21)	10 (9, 16)	14 (7, 21)	0 (0, 0)	7 (4, 14)	2 (1, 3)	0 (0, 1)	3 (1, 4)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.27 (0.04, 0.49)	0.27 (0.17, 0.39)	0.4 (0.21, 0.48)	0.34 (0.11, 0.47)	0.24 (0.04, 0.44)	0.19 (0.06, 0.42)	0.27 (0.19, 0.39)	0.27 (0.16, 0.34)	0.36 (0.25, 0.45)	NA (NA, NA)	0.38 (0.18, 0.48)	0.44 (0.25, 0.47)	0.45 (0.45, 0.45)	0.45 (0.38, 0.48)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.025 (0.021, 0.031)	0.032 (0.023, 0.039)	0.031 (0.023, 0.043)	0.029 (0.017, 0.038)	0.027 (0.018, 0.05)	0.029 (0.019, 0.039)	0.031 (0.021, 0.035)	0.029 (0.019, 0.049)	0.024 (0.02, 0.03)	NA (NA, NA)	0.03 (0.027, 0.048)	0.047 (0.013, 0.072)	0.036 (0, 0.084)	0.039 (0.017, 0.048)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
all	TC2	time	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)	43 (24, 46)
all	TC2	n	29 (20, 29)	7 (6, 17)	4 (1, 5)	24 (14, 43)	12 (10, 14)	15 (10, 20)	10 (9, 13)	7 (6, 10)	12 (8, 15)	0 (0, 0)	11 (7, 12)	2 (0, 4)	1 (0, 1)	1 (0, 6)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.22 (0.14, 0.26)	0.31 (0.22, 0.4)	0.38 (0.36, 0.39)	0.45 (0.38, 0.46)	0.11 (0.03, 0.4)	0.4 (0.34, 0.42)	0.27 (0.22, 0.33)	0.22 (0.14, 0.32)	0.34 (0.31, 0.42)	NA (NA, NA)	0.45 (0.4, 0.49)	0.45 (0.42, 0.48)	0.45 (0.45, 0.45)	0.35 (0.3, 0.41)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.026 (0.026, 0.029)	0.022 (0.022, 0.048)	0.038 (0.034, 0.042)	0.017 (0.012, 0.018)	0.038 (0.022, 0.043)	0.023 (0.018, 0.03)	0.03 (0.028, 0.034)	0.041 (0.034, 0.046)	0.031 (0.022, 0.046)	NA (NA, NA)	0.017 (0.016, 0.023)	0.067 (0.026, 0.109)	0 (0, 0)	0.039 (0.036, 0.042)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC3	time	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)	38 (36, 52)
all	TC3	n	41 (21, 83)	10 (6, 13)	4 (2, 10)	20 (17, 30)	20 (12, 25)	10 (8, 14)	9 (5, 22)	13 (8, 28)	13 (10, 15)	0 (0, 0)	13 (6, 14)	2 (0, 5)	0 (0, 1)	2 (2, 3)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.35 (0.1, 0.43)	0.34 (0.21, 0.39)	0.48 (0.47, 0.49)	0.45 (0.31, 0.48)	0.4 (0.11, 0.42)	0.2 (0.07, 0.37)	0.33 (0.09, 0.41)	0.16 (0.11, 0.38)	0.29 (0.24, 0.46)	NA (NA, NA)	0.23 (0.1, 0.35)	0.43 (0.42, 0.45)	0.5 (0.5, 0.5)	0.48 (0.48, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.021 (0.02, 0.033)	0.027 (0.026, 0.07)	0.023 (0.015, 0.04)	0.024 (0.019, 0.025)	0.029 (0.023, 0.035)	0.035 (0.025, 0.049)	0.023 (0.02, 0.083)	0.035 (0.025, 0.049)	0.026 (0.022, 0.032)	NA (NA, NA)	0.027 (0.022, 0.031)	0.02 (0.018, 0.127)	0 (0, 0)	0.041 (0.005, 0.044)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
all	TC4	time	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)	48 (29, 49)
all	TC4	n	32 (21, 90)	14 (9, 29)	4 (3, 9)	14 (12, 37)	15 (10, 32)	11 (9, 29)	6 (4, 12)	9 (6, 16)	15 (7, 30)	0 (0, 0)	10 (5, 10)	4 (2, 6)	0 (0, 2)	3 (0, 4)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.21 (0.05, 0.45)	0.42 (0.25, 0.5)	0.48 (0.43, 0.49)	0.33 (0.18, 0.49)	0.37 (0.25, 0.41)	0.22 (0.09, 0.42)	0.45 (0.33, 0.49)	0.34 (0.12, 0.39)	0.36 (0.2, 0.42)	NA (NA, NA)	0.46 (0.18, 0.46)	0.47 (0.33, 0.48)	NA (NA, NA)	0.44 (0.35, 0.47)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.022 (0.019, 0.036)	0.018 (0.017, 0.028)	0.028 (0.018, 0.035)	0.018 (0.016, 0.029)	0.027 (0.022, 0.035)	0.031 (0.021, 0.049)	0.022 (0.02, 0.046)	0.038 (0.026, 0.047)	0.021 (0.018, 0.051)	NA (NA, NA)	0.03 (0.024, 0.042)	0.024 (0.015, 0.053)	0 (0, 0)	0.057 (0.016, 0.104)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									6	6	6	6	6	6	6	6
HRD+	TC1	time									58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)	58 (54, 60)
HRD+	TC1	n									20 (14, 36)	0 (0, 0)	22 (12, 26)	4 (2, 4)	0 (0, 0)	6 (3, 10)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.35 (0.11, 0.47)	NA (NA, NA)	0.37 (0.2, 0.47)	0.43 (0.37, 0.45)	0.44 (0.44, 0.44)	0.47 (0.33, 0.5)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.025 (0.019, 0.046)	NA (NA, NA)	0.027 (0.023, 0.042)	0.035 (0.021, 0.042)	0.176 (0.176, 0.176)	0.024 (0.018, 0.049)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									8	8	8	8	8	8	8	8
HRD+	TC2	time									56 (51, 60)	56 (51, 60)	56 (51, 60)	56 (51, 60)	56 (51, 60)	56 (51, 60)	56 (51, 60)	56 (51, 60)
HRD+	TC2	n									36 (21, 42)	0 (0, 0)	14 (7, 31)	3 (0, 6)	0 (0, 1)	4 (1, 5)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.36 (0.3, 0.47)	NA (NA, NA)	0.29 (0.23, 0.4)	0.42 (0.21, 0.49)	0.45 (0.43, 0.47)	0.42 (0.28, 0.48)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.022 (0.017, 0.027)	NA (NA, NA)	0.026 (0.018, 0.032)	0.033 (0.017, 0.085)	0.031 (0, 0.475)	0.033 (0.015, 0.076)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									8	8	8	8	8	8	8	8
HRD+	TC3	time									52 (47, 58)	52 (47, 58)	52 (47, 58)	52 (47, 58)	52 (47, 58)	52 (47, 58)	52 (47, 58)	52 (47, 58)
HRD+	TC3	n									30 (22, 36)	0 (0, 0)	14 (11, 22)	4 (2, 6)	0 (0, 2)	2 (1, 6)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.42 (0.36, 0.45)	NA (NA, NA)	0.32 (0.16, 0.46)	0.42 (0.25, 0.48)	0.45 (0.43, 0.48)	0.41 (0.29, 0.45)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.02 (0.017, 0.025)	NA (NA, NA)	0.024 (0.016, 0.032)	0.03 (0.018, 0.045)	0.018 (0.005, 0.065)	0.06 (0.027, 0.089)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									5	5	5	5	5	5	5	5
HRD+	TC4	time									55 (50, 59)	55 (50, 59)	55 (50, 59)	55 (50, 59)	55 (50, 59)	55 (50, 59)	55 (50, 59)	55 (50, 59)
HRD+	TC4	n									27 (21, 36)	0 (0, 0)	18 (13, 19)	4 (1, 7)	1 (0, 2)	8 (2, 11)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.34 (0.27, 0.43)	NA (NA, NA)	0.34 (0.16, 0.47)	0.44 (0.34, 0.45)	0.46 (0.46, 0.46)	0.47 (0.26, 0.48)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.022 (0.017, 0.024)	NA (NA, NA)	0.019 (0.017, 0.025)	0.027 (0.021, 0.093)	0.049 (0.01, 0.054)	0.03 (0.017, 0.052)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					75	75	75	75					75	75	75	75
TP53+	TC1	time					40 (28, 56)	40 (28, 56)	40 (28, 56)	40 (28, 56)					40 (28, 56)	40 (28, 56)	40 (28, 56)	40 (28, 56)
TP53+	TC1	n					20 (11, 51)	15 (8, 31)	13 (8, 25)	11 (7, 19)					0 (0, 2)	3 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.33 (0.08, 0.45)	0.32 (0.06, 0.47)	0.35 (0.14, 0.46)	0.38 (0.17, 0.47)					0.47 (0.43, 0.49)	0.45 (0.37, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.024 (0.019, 0.041)	0.025 (0.016, 0.045)	0.026 (0.019, 0.037)	0.026 (0.018, 0.045)					0 (0, 0.073)	0.026 (0, 0.049)	NA (NA, NA)	0.044 (0.009, 0.054)
TP53+	TC2	count					91	91	91	91					91	91	91	91
TP53+	TC2	time					33 (21, 50)	33 (21, 50)	33 (21, 50)	33 (21, 50)					33 (21, 50)	33 (21, 50)	33 (21, 50)	33 (21, 50)
TP53+	TC2	n					21 (13, 34)	13 (8, 27)	14 (9, 24)	11 (6, 21)					0 (0, 1)	2 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.31 (0.11, 0.47)	0.39 (0.19, 0.49)	0.34 (0.16, 0.47)	0.39 (0.15, 0.48)					0.48 (0.45, 0.5)	0.44 (0.39, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.023 (0.017, 0.036)	0.024 (0.017, 0.037)	0.024 (0.017, 0.035)	0.026 (0.016, 0.041)					0 (0, 0.071)	0.031 (0, 0.1)	NA (NA, NA)	0 (0, 0)
TP53+	TC3	count					62	62	62	62					62	62	62	62
TP53+	TC3	time					40 (30, 52)	40 (30, 52)	40 (30, 52)	40 (30, 52)					40 (30, 52)	40 (30, 52)	40 (30, 52)	40 (30, 52)
TP53+	TC3	n					22 (11, 40)	15 (8, 27)	13 (7, 20)	10 (6, 17)					1 (0, 2)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.34 (0.18, 0.48)	0.32 (0.13, 0.45)	0.38 (0.14, 0.5)	0.35 (0.16, 0.48)					0.47 (0.43, 0.5)	0.44 (0.37, 0.48)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.023 (0.018, 0.034)	0.025 (0.017, 0.042)	0.025 (0.018, 0.038)	0.025 (0.016, 0.046)					0.021 (0, 0.083)	0.032 (0.009, 0.11)	0 (0, 0)	0.181 (0.036, 0.327)
TP53+	TC4	count					90	90	90	90					90	90	90	90
TP53+	TC4	time					39 (28, 54)	39 (28, 54)	39 (28, 54)	39 (28, 54)					39 (28, 54)	39 (28, 54)	39 (28, 54)	39 (28, 54)
TP53+	TC4	n					25 (13, 45)	15 (9, 26)	13 (7, 28)	12 (6, 20)					0 (0, 1)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.39 (0.16, 0.49)	0.31 (0.09, 0.47)	0.38 (0.19, 0.48)	0.36 (0.16, 0.48)					0.46 (0.41, 0.49)	0.43 (0.31, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.022 (0.017, 0.033)	0.024 (0.017, 0.042)	0.025 (0.018, 0.037)	0.025 (0.017, 0.035)					0 (0, 0.069)	0.028 (0.01, 0.072)	0 (0, 0)	0 (0, 0)
TEfus+	TC1	count			41	41			41	41			41	41			41	41
TEfus+	TC1	time			47 (34, 58)	47 (34, 58)			47 (34, 58)	47 (34, 58)			47 (34, 58)	47 (34, 58)			47 (34, 58)	47 (34, 58)
TEfus+	TC1	n			5 (3, 8)	20 (10, 53)			17 (8, 30)	13 (8, 21)			9 (4, 22)	2 (0, 4)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.41 (0.23, 0.48)	0.36 (0.13, 0.46)			0.33 (0.14, 0.44)	0.38 (0.23, 0.48)			0.4 (0.23, 0.49)	0.44 (0.33, 0.5)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.032 (0.018, 0.053)	0.022 (0.018, 0.032)			0.027 (0.019, 0.04)	0.025 (0.017, 0.034)			0.027 (0.018, 0.039)	0.027 (0, 0.109)			NA (NA, NA)	0 (0, 0)
TEfus+	TC2	count			52	52			52	52			52	52			52	52
TEfus+	TC2	time			43 (28, 59)	43 (28, 59)			43 (28, 59)	43 (28, 59)			43 (28, 59)	43 (28, 59)			43 (28, 59)	43 (28, 59)
TEfus+	TC2	n			5 (3, 11)	18 (10, 34)			14 (8, 24)	11 (7, 20)			8 (4, 16)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.42 (0.23, 0.47)	0.34 (0.11, 0.47)			0.34 (0.08, 0.47)	0.32 (0.1, 0.48)			0.42 (0.19, 0.49)	0.46 (0.36, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.028 (0.014, 0.045)	0.023 (0.018, 0.036)			0.026 (0.016, 0.042)	0.028 (0.017, 0.045)			0.024 (0.016, 0.048)	0.027 (0, 0.106)			NA (NA, NA)	0.469 (0.469, 0.469)
TEfus+	TC3	count			52	52			52	52			52	52			52	52
TEfus+	TC3	time			42 (31, 55)	42 (31, 55)			42 (31, 55)	42 (31, 55)			42 (31, 55)	42 (31, 55)			42 (31, 55)	42 (31, 55)
TEfus+	TC3	n			4 (2, 8)	18 (10, 31)			13 (7, 25)	12 (6, 18)			10 (6, 18)	3 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.44 (0.33, 0.49)	0.36 (0.19, 0.48)			0.36 (0.12, 0.48)	0.36 (0.13, 0.48)			0.28 (0.13, 0.47)	0.45 (0.37, 0.48)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.03 (0.017, 0.075)	0.025 (0.018, 0.035)			0.025 (0.018, 0.04)	0.025 (0.017, 0.048)			0.028 (0.018, 0.046)	0.03 (0.014, 0.082)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			40	40			40	40			40	40			40	40
TEfus+	TC4	time			46 (36, 56)	46 (36, 56)			46 (36, 56)	46 (36, 56)			46 (36, 56)	46 (36, 56)			46 (36, 56)	46 (36, 56)
TEfus+	TC4	n			5 (1, 6)	20 (13, 35)			14 (8, 30)	12 (6, 22)			8 (6, 15)	2 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.43 (0.24, 0.49)	0.27 (0.07, 0.47)			0.37 (0.13, 0.49)	0.31 (0.18, 0.45)			0.37 (0.1, 0.49)	0.44 (0.35, 0.48)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.032 (0.015, 0.16)	0.024 (0.016, 0.038)			0.025 (0.018, 0.041)	0.025 (0.018, 0.037)			0.027 (0.02, 0.047)	0.032 (0.016, 0.082)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		56		56		56		56		56		56		56		56
PI3K+	TC1	time		43 (28, 58)		43 (28, 58)		43 (28, 58)		43 (28, 58)		43 (28, 58)		43 (28, 58)		43 (28, 58)		43 (28, 58)
PI3K+	TC1	n		14 (8, 25)		16 (9, 31)		15 (10, 35)		10 (6, 19)		0 (0, 0)		2 (0, 4)		3 (1, 6)		0 (0, 0)
PI3K+	TC1	post_p		0.37 (0.16, 0.48)		0.37 (0.2, 0.49)		0.37 (0.12, 0.46)		0.34 (0.12, 0.47)		NA (NA, NA)		0.44 (0.33, 0.49)		0.46 (0.34, 0.49)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.026 (0.019, 0.04)		0.023 (0.018, 0.033)		0.023 (0.018, 0.036)		0.028 (0.018, 0.064)		NA (NA, NA)		0.041 (0, 0.097)		0.029 (0.013, 0.077)		0 (0, 0.045)
PI3K+	TC2	count		64		64		64		64		64		64		64		64
PI3K+	TC2	time		45 (27, 55)		45 (27, 55)		45 (27, 55)		45 (27, 55)		45 (27, 55)		45 (27, 55)		45 (27, 55)		45 (27, 55)
PI3K+	TC2	n		11 (7, 26)		17 (10, 37)		14 (9, 28)		11 (6, 24)		0 (0, 0)		3 (0, 6)		3 (1, 7)		0 (0, 0)
PI3K+	TC2	post_p		0.34 (0.1, 0.48)		0.33 (0.11, 0.45)		0.33 (0.11, 0.48)		0.35 (0.09, 0.47)		NA (NA, NA)		0.44 (0.36, 0.49)		0.44 (0.32, 0.49)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.026 (0.018, 0.043)		0.025 (0.017, 0.034)		0.024 (0.017, 0.04)		0.026 (0.018, 0.042)		NA (NA, NA)		0.025 (0.013, 0.105)		0.028 (0.012, 0.095)		NA (NA, NA)
PI3K+	TC3	count		49		49		49		49		49		49		49		49
PI3K+	TC3	time		39 (31, 54)		39 (31, 54)		39 (31, 54)		39 (31, 54)		39 (31, 54)		39 (31, 54)		39 (31, 54)		39 (31, 54)
PI3K+	TC3	n		12 (5, 26)		19 (10, 33)		12 (8, 26)		11 (6, 20)		0 (0, 0)		3 (1, 5)		3 (2, 6)		0 (0, 0)
PI3K+	TC3	post_p		0.34 (0.2, 0.45)		0.35 (0.16, 0.47)		0.33 (0.12, 0.47)		0.35 (0.12, 0.48)		NA (NA, NA)		0.44 (0.36, 0.49)		0.44 (0.35, 0.48)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.026 (0.019, 0.046)		0.024 (0.018, 0.03)		0.025 (0.017, 0.04)		0.025 (0.018, 0.043)		NA (NA, NA)		0.031 (0.015, 0.09)		0.031 (0.012, 0.068)		0 (0, 0)
PI3K+	TC4	count		81		81		81		81		81		81		81		81
PI3K+	TC4	time		36 (25, 51)		36 (25, 51)		36 (25, 51)		36 (25, 51)		36 (25, 51)		36 (25, 51)		36 (25, 51)		36 (25, 51)
PI3K+	TC4	n		13 (8, 25)		18 (12, 32)		16 (10, 29)		12 (6, 20)		0 (0, 0)		2 (0, 5)		4 (1, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.32 (0.13, 0.46)		0.36 (0.14, 0.47)		0.35 (0.13, 0.48)		0.37 (0.19, 0.47)		NA (NA, NA)		0.46 (0.37, 0.5)		0.43 (0.31, 0.49)		NA (NA, NA)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.026 (0.017, 0.038)		0.024 (0.017, 0.033)		0.023 (0.017, 0.037)		0.023 (0.017, 0.042)		NA (NA, NA)		0.032 (0, 0.088)		0.027 (0.013, 0.083)		0 (0, 0)