Setting description

Treatments equally effective across the biomarker signatures

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
all summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
all effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
HRD+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
HRD+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
TP53+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
TEfus+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
PI3K+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
—- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
—+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
–+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
–++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
-+– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
-+-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
-++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
-+++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
+— effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
+–+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
+-+- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
+-++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
++– effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
++-+ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
+++- effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 39, median = 31.9
++++ effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 17 10 16 18
HRD+ 16 16 12 14
TP53+ 13 11 21 11
TEfus+ 19 5 13 9
PI3K+ 11 12 9 4
TC1 TC2 TC3 TC4
all 0.034 0.020 0.032 0.036
HRD+ 0.032 0.032 0.024 0.028
TP53+ 0.026 0.022 0.042 0.022
TEfus+ 0.038 0.010 0.026 0.018
PI3K+ 0.022 0.024 0.018 0.008
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 8 3 5 5
HRD+ 6 8 8 5
TP53+ 75 91 62 90
TEfus+ 41 52 52 40
PI3K+ 56 64 49 81
TC1 TC2 TC3 TC4
all 0.016 0.006 0.010 0.010
HRD+ 0.012 0.016 0.016 0.010
TP53+ 0.150 0.182 0.124 0.180
TEfus+ 0.082 0.104 0.104 0.080
PI3K+ 0.112 0.128 0.098 0.162
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.4 0.134 0.096 0.13 0.104
Error subgroup 0.4 0.134 0.096 0.13 0.104
Power signature 0.0 0.000 0.000 0.00 0.000
Power subgroup 0.0 0.000 0.000 0.00 0.000

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 17 10 16 18
all futility 0 8 3 5 5
all max_n 0 0 0 0 0
all n 603 (554, 657) 288 (202, 392) 308 (208, 403) 294 (204, 394) 300 (207, 397)
all n_unique 603 (554, 657) 288 (202, 392) 308 (208, 403) 294 (204, 394) 300 (207, 397)
all time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60)
all time_stop NA (NA, NA) 25 (11, 52) 12 (9, 43) 15 (11, 38) 17 (11, 48)
all post_p NA (NA, NA) 0.48 (0.08, 0.89) 0.49 (0.09, 0.88) 0.49 (0.1, 0.89) 0.46 (0.09, 0.9)
all rate 0.021 (0.019, 0.022) 0.022 (0.019, 0.024) 0.021 (0.019, 0.024) 0.021 (0.019, 0.024) 0.021 (0.019, 0.024)
HRD+ graduation 0 16 16 12 14
HRD+ futility 0 6 8 8 5
HRD+ max_n 0 0 0 0 0
HRD+ n 82 (68, 96) 42 (26, 62) 44 (27, 60) 47 (33, 65) 43 (26, 61)
HRD+ n_unique 82 (68, 96) 42 (26, 62) 44 (27, 60) 47 (33, 65) 43 (26, 61)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 56 (48, 59) 53 (46, 60) 50 (46, 60) 55 (50, 59)
HRD+ post_p NA (NA, NA) 0.52 (0.11, 0.87) 0.49 (0.13, 0.87) 0.5 (0.13, 0.87) 0.52 (0.11, 0.88)
HRD+ rate 0.021 (0.017, 0.025) 0.021 (0.016, 0.03) 0.021 (0.016, 0.029) 0.022 (0.017, 0.028) 0.021 (0.016, 0.029)
TP53+ graduation 0 13 11 21 11
TP53+ futility 0 75 91 62 90
TP53+ max_n 0 0 0 0 0
TP53+ n 225 (196, 256) 110 (59, 159) 117 (62, 164) 110 (58, 161) 111 (60, 156)
TP53+ n_unique 225 (196, 256) 110 (59, 159) 117 (62, 164) 110 (58, 161) 111 (60, 156)
TP53+ time_trial 60 (60, 60) 60 (42, 60) 60 (35, 60) 60 (41, 60) 60 (39, 60)
TP53+ time_stop NA (NA, NA) 39 (27, 55) 36 (21, 51) 38 (26, 52) 39 (27, 54)
TP53+ post_p NA (NA, NA) 0.47 (0.11, 0.87) 0.47 (0.09, 0.9) 0.53 (0.11, 0.92) 0.49 (0.1, 0.9)
TP53+ rate 0.021 (0.018, 0.023) 0.021 (0.018, 0.026) 0.022 (0.018, 0.027) 0.021 (0.017, 0.026) 0.021 (0.018, 0.026)
TEfus+ graduation 0 19 5 13 9
TEfus+ futility 0 41 52 52 40
TEfus+ max_n 0 0 0 0 0
TEfus+ n 192 (170, 217) 97 (58, 134) 100 (58, 139) 97 (58, 136) 97 (60, 139)
TEfus+ n_unique 192 (170, 217) 97 (58, 134) 100 (58, 139) 97 (58, 136) 97 (60, 139)
TEfus+ time_trial 60 (60, 60) 60 (54, 60) 60 (57, 60) 60 (48, 60) 60 (60, 60)
TEfus+ time_stop NA (NA, NA) 42 (29, 57) 42 (25, 58) 40 (29, 54) 44 (31, 56)
TEfus+ post_p NA (NA, NA) 0.48 (0.09, 0.87) 0.46 (0.09, 0.88) 0.49 (0.11, 0.89) 0.49 (0.1, 0.89)
TEfus+ rate 0.021 (0.018, 0.024) 0.021 (0.017, 0.026) 0.022 (0.018, 0.027) 0.021 (0.018, 0.026) 0.021 (0.018, 0.026)
PI3K+ graduation 0 11 12 9 4
PI3K+ futility 0 56 64 49 81
PI3K+ max_n 0 0 0 0 0
PI3K+ n 208 (183, 236) 104 (60, 145) 108 (59, 148) 106 (59, 146) 108 (60, 154)
PI3K+ n_unique 208 (183, 236) 104 (60, 145) 108 (59, 148) 106 (59, 146) 108 (60, 154)
PI3K+ time_trial 60 (60, 60) 60 (51, 60) 60 (47, 60) 60 (52, 60) 60 (38, 60)
PI3K+ time_stop NA (NA, NA) 42 (28, 56) 44 (28, 54) 37 (30, 53) 36 (24, 51)
PI3K+ post_p NA (NA, NA) 0.46 (0.07, 0.88) 0.45 (0.08, 0.87) 0.51 (0.1, 0.87) 0.49 (0.07, 0.87)
PI3K+ rate 0.02 (0.018, 0.023) 0.021 (0.018, 0.026) 0.022 (0.018, 0.026) 0.021 (0.017, 0.026) 0.022 (0.018, 0.027)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 17 10 16 18
—- futility 0 8 3 5 5
—- max_n 0 0 0 0 0
—- n 188 (156, 222) 73 (30, 160) 88 (29, 166) 71 (23, 157) 85 (25, 163)
—- n_unique 188 (156, 222) 73 (30, 160) 88 (29, 166) 71 (23, 157) 85 (25, 163)
—- post_p NA (NA, NA) 0.42 (0.09, 0.87) 0.5 (0.08, 0.88) 0.43 (0.07, 0.86) 0.45 (0.08, 0.87)
—- rate 0.021 (0.018, 0.024) 0.022 (0.018, 0.029) 0.022 (0.017, 0.029) 0.022 (0.017, 0.03) 0.021 (0.017, 0.029)
—+ graduation 0 26 21 25 22
—+ futility 0 57 65 49 82
—+ max_n 0 0 0 0 0
—+ n 42 (31, 54) 21 (10, 39) 18 (8, 38) 20 (7, 39) 19 (9, 39)
—+ n_unique 42 (31, 54) 21 (10, 39) 18 (8, 38) 20 (7, 39) 19 (9, 39)
—+ post_p NA (NA, NA) 0.49 (0.14, 0.85) 0.43 (0.13, 0.85) 0.49 (0.11, 0.86) 0.47 (0.13, 0.83)
—+ rate 0.021 (0.015, 0.028) 0.022 (0.015, 0.034) 0.023 (0.015, 0.038) 0.021 (0.014, 0.036) 0.022 (0.015, 0.035)
–+- graduation 0 33 14 29 27
–+- futility 0 43 53 52 43
–+- max_n 0 0 0 0 0
–+- n 12 (7, 17) 6 (3, 12) 8 (4, 14) 6 (3, 11) 6 (3, 12)
–+- n_unique 12 (7, 17) 6 (3, 12) 8 (4, 14) 6 (3, 11) 6 (3, 12)
–+- post_p NA (NA, NA) 0.49 (0.2, 0.8) 0.47 (0.2, 0.79) 0.47 (0.21, 0.8) 0.51 (0.22, 0.75)
–+- rate 0.021 (0.011, 0.035) 0.023 (0.009, 0.048) 0.022 (0.01, 0.043) 0.023 (0.008, 0.048) 0.021 (0.009, 0.047)
–++ graduation 0 41 24 36 29
–++ futility 0 86 99 83 107
–++ max_n 0 0 0 0 0
–++ n 62 (50, 77) 27 (11, 56) 28 (11, 58) 26 (11, 57) 28 (12, 58)
–++ n_unique 62 (50, 77) 27 (11, 56) 28 (11, 58) 26 (11, 57) 28 (12, 58)
–++ post_p NA (NA, NA) 0.44 (0.11, 0.83) 0.46 (0.11, 0.86) 0.47 (0.14, 0.86) 0.46 (0.11, 0.86)
–++ rate 0.02 (0.016, 0.026) 0.022 (0.016, 0.035) 0.022 (0.015, 0.034) 0.022 (0.015, 0.033) 0.022 (0.016, 0.034)
-+– graduation 0 27 20 37 27
-+– futility 0 76 92 63 91
-+– max_n 0 0 0 0 0
-+– n 78 (63, 97) 35 (14, 68) 34 (15, 72) 34 (13, 68) 34 (13, 64)
-+– n_unique 78 (63, 97) 35 (14, 68) 34 (15, 72) 34 (13, 68) 34 (13, 64)
-+– post_p NA (NA, NA) 0.48 (0.11, 0.85) 0.49 (0.12, 0.87) 0.5 (0.13, 0.86) 0.48 (0.11, 0.86)
-+– rate 0.021 (0.017, 0.025) 0.022 (0.016, 0.032) 0.022 (0.017, 0.033) 0.021 (0.016, 0.031) 0.022 (0.016, 0.033)
-+-+ graduation 0 35 29 46 30
-+-+ futility 0 106 127 92 138
-+-+ max_n 0 0 0 0 0
-+-+ n 52 (42, 65) 21 (9, 49) 24 (10, 50) 23 (9, 47) 23 (10, 47)
-+-+ n_unique 52 (42, 65) 21 (9, 49) 24 (10, 50) 23 (9, 47) 23 (10, 47)
-+-+ post_p NA (NA, NA) 0.46 (0.11, 0.86) 0.48 (0.13, 0.86) 0.49 (0.11, 0.89) 0.46 (0.11, 0.86)
-+-+ rate 0.02 (0.015, 0.026) 0.022 (0.015, 0.038) 0.022 (0.015, 0.034) 0.021 (0.014, 0.035) 0.023 (0.016, 0.034)
-++- graduation 0 42 24 46 34
-++- futility 0 104 130 100 114
-++- max_n 0 0 0 0 0
-++- n 48 (36, 59) 22 (8, 42) 21 (10, 44) 19 (8, 41) 20 (8, 42)
-++- n_unique 48 (36, 59) 22 (8, 42) 21 (10, 44) 19 (8, 41) 20 (8, 42)
-++- post_p NA (NA, NA) 0.5 (0.16, 0.86) 0.46 (0.13, 0.85) 0.5 (0.14, 0.87) 0.51 (0.13, 0.87)
-++- rate 0.021 (0.016, 0.028) 0.022 (0.015, 0.035) 0.023 (0.016, 0.035) 0.022 (0.014, 0.034) 0.022 (0.014, 0.038)
-+++ graduation 0 49 32 53 36
-+++ futility 0 133 156 121 156
-+++ max_n 0 0 0 0 0
-+++ n 37 (27, 47) 15 (6, 32) 16 (7, 34) 16 (6, 34) 16 (8, 36)
-+++ n_unique 37 (27, 47) 15 (6, 32) 16 (7, 34) 16 (6, 34) 16 (8, 36)
-+++ post_p NA (NA, NA) 0.47 (0.13, 0.84) 0.44 (0.12, 0.84) 0.49 (0.15, 0.86) 0.45 (0.15, 0.85)
-+++ rate 0.02 (0.014, 0.027) 0.022 (0.013, 0.04) 0.023 (0.014, 0.039) 0.022 (0.013, 0.038) 0.022 (0.014, 0.034)
+— graduation 0 33 26 28 32
+— futility 0 14 11 13 10
+— max_n 0 0 0 0 0
+— n 39 (30, 50) 18 (7, 34) 20 (9, 35) 21 (10, 36) 18 (8, 32)
+— n_unique 39 (30, 50) 18 (7, 34) 20 (9, 35) 21 (10, 36) 18 (8, 32)
+— post_p NA (NA, NA) 0.49 (0.13, 0.85) 0.5 (0.13, 0.86) 0.5 (0.15, 0.84) 0.48 (0.16, 0.84)
+— rate 0.021 (0.016, 0.029) 0.022 (0.014, 0.038) 0.022 (0.014, 0.034) 0.022 (0.015, 0.033) 0.022 (0.014, 0.036)
+–+ graduation 0 42 37 34 36
+–+ futility 0 63 69 55 87
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+–+ rate 0.047 (0.047, 0.047) 0 (0, 0) 0.029 (0, 0.34) 0 (0, 0.058) 0.058 (0.058, 0.058)
+-+- graduation 0 49 29 40 39
+-+- futility 0 47 58 59 48
+-+- max_n 0 0 0 0 0
+-+- n 27 (20, 36) 13 (6, 25) 13 (6, 24) 15 (7, 25) 13 (6, 24)
+-+- n_unique 27 (20, 36) 13 (6, 25) 13 (6, 24) 15 (7, 25) 13 (6, 24)
+-+- post_p NA (NA, NA) 0.5 (0.18, 0.84) 0.48 (0.17, 0.84) 0.47 (0.15, 0.86) 0.5 (0.15, 0.82)
+-+- rate 0.021 (0.014, 0.03) 0.022 (0.012, 0.038) 0.022 (0.012, 0.04) 0.022 (0.014, 0.036) 0.022 (0.013, 0.039)
+-++ graduation 0 57 39 46 41
+-++ futility 0 90 102 88 112
+-++ max_n 0 0 0 0 0
+-++ n 6 (3, 10) 3 (1, 7) 3 (1, 7) 4 (1, 7) 4 (1, 7)
+-++ n_unique 6 (3, 10) 3 (1, 7) 3 (1, 7) 4 (1, 7) 4 (1, 7)
+-++ post_p NA (NA, NA) 0.5 (0.29, 0.69) 0.49 (0.3, 0.68) 0.48 (0.32, 0.67) 0.48 (0.31, 0.69)
+-++ rate 0.021 (0.004, 0.042) 0.021 (0, 0.068) 0.022 (0, 0.069) 0.021 (0, 0.064) 0.023 (0, 0.059)
++– graduation 0 43 35 49 41
++– futility 0 80 95 68 94
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
++– n_unique 1 (0, 3) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2)
++– post_p NA (NA, NA) 0.5 (0.43, 0.57) 0.5 (0.43, 0.57) 0.5 (0.43, 0.57) 0.5 (0.44, 0.58)
++– rate 0.016 (0, 0.107) 0.019 (0, 0.11) 0.017 (0, 0.096) 0.02 (0, 0.105) 0.016 (0, 0.096)
++-+ graduation 0 51 44 55 44
++-+ futility 0 110 128 95 141
++-+ max_n 0 0 0 0 0
++-+ n 8 (4, 12) 4 (1, 9) 4 (1, 9) 5 (2, 9) 5 (2, 9)
++-+ n_unique 8 (4, 12) 4 (1, 9) 4 (1, 9) 5 (2, 9) 5 (2, 9)
++-+ post_p NA (NA, NA) 0.49 (0.28, 0.73) 0.49 (0.29, 0.74) 0.47 (0.28, 0.72) 0.48 (0.27, 0.73)
++-+ rate 0.02 (0.007, 0.037) 0.022 (0, 0.055) 0.021 (0.006, 0.061) 0.023 (0.008, 0.062) 0.022 (0.008, 0.057)
+++- graduation 0 58 38 57 46
+++- futility 0 106 133 104 117
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44)
+++- rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.021) 0.05 (0.01, 0.059)
++++ graduation 0 65 46 63 48
++++ futility 0 135 157 123 159
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) 0.45 (0.45, 0.45) 0.51 (0.5, 0.52) 0.51 (0.43, 0.51) 0.5 (0.5, 0.5)
++++ rate 0 (0, 0.023) 0.035 (0, 0.059) 0.028 (0, 0.384) 0.045 (0, 0.251) 0 (0, 0.106)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 17 10 16 18
all time_stop 16 (10, 39) 11 (9, 37) 14 (10, 17) 16 (11, 33)
all n_trt 97 (67, 244) 66 (58, 225) 66 (52, 99) 74 (60, 186)
all n_control 136 (79, 374) 92 (75, 319) 118 (82, 141) 124 (93, 285)
all post_p 0.94 (0.87, 0.99) 0.92 (0.9, 0.93) 0.92 (0.87, 0.96) 0.95 (0.89, 0.98)
all order 1 (1, 2) 1 (1, 1.1) 1 (1, 1) 1 (1, 1.3)
HRD+ count 16 16 12 14
HRD+ time_stop 52 (48, 58) 50 (45, 60) 49 (44, 60) 56 (50, 59)
HRD+ n_trt 52 (50, 60) 52 (50, 54) 52 (50, 58) 54 (50, 61)
HRD+ n_control 68 (57, 76) 64 (43, 80) 64 (49, 79) 68 (59, 83)
HRD+ post_p 0.92 (0.86, 0.98) 0.97 (0.87, 0.99) 0.94 (0.87, 0.99) 0.95 (0.9, 0.96)
HRD+ order 1 (1, 3) 1 (1, 2) 1 (1, 2) 1 (1, 2)
TP53+ count 13 11 21 11
TP53+ time_stop 28 (20, 40) 44 (32, 51) 29 (23, 52) 37 (21, 52)
TP53+ n_trt 59 (51, 75) 122 (72, 135) 62 (52, 98) 88 (52, 110)
TP53+ n_control 74 (62, 119) 136 (113, 167) 91 (67, 170) 124 (64, 169)
TP53+ post_p 0.95 (0.88, 0.99) 0.98 (0.94, 0.99) 0.95 (0.88, 0.98) 0.97 (0.91, 1)
TP53+ order 1 (1, 1) 1 (1, 2) 1 (1, 2) 1 (1, 2)
TEfus+ count 19 5 13 9
TEfus+ time_stop 31 (26, 48) 29 (20, 49) 32 (27, 48) 32 (29, 53)
TEfus+ n_trt 66 (51, 96) 60 (52, 103) 62 (54, 99) 60 (54, 102)
TEfus+ n_control 87 (64, 136) 77 (53, 148) 88 (67, 121) 87 (72, 145)
TEfus+ post_p 0.95 (0.89, 0.99) 0.95 (0.9, 0.99) 0.98 (0.9, 1) 0.95 (0.92, 0.99)
TEfus+ order 1 (1, 2) 1 (1, 2.2) 1 (1, 3) 1 (1, 2)
PI3K+ count 11 12 9 4
PI3K+ time_stop 31 (25, 48) 38 (30, 52) 30 (26, 48) 34 (22, 42)
PI3K+ n_trt 70 (52, 96) 78 (57, 92) 60 (51, 132) 92 (65, 116)
PI3K+ n_control 92 (67, 166) 116 (95, 151) 90 (75, 145) 94 (65, 123)
PI3K+ post_p 0.98 (0.93, 0.99) 0.98 (0.96, 0.99) 0.96 (0.93, 0.99) 0.98 (0.93, 0.99)
PI3K+ order 1 (1, 2) 1 (1, 2.9) 1 (1, 2) 1 (1, 1)
Futility:
signature var TC1 TC2 TC3 TC4
all count 8 3 5 5
all time_stop 48 (31, 53) 43 (24, 46) 38 (36, 52) 48 (29, 49)
all n_trt 158 (145, 177) 163 (105, 165) 181 (131, 211) 185 (131, 229)
all n_control 462 (289, 509) 407 (213, 468) 362 (343, 489) 480 (262, 559)
all post_p 0.01 (0, 0.04) 0.01 (0, 0.02) 0.02 (0.01, 0.16) 0.02 (0.01, 0.14)
all order 3 (1, 5.3) 2 (1.2, 2) 4 (3, 4) 4 (1.4, 5.6)
HRD+ count 6 8 8 5
HRD+ time_stop 58 (54, 60) 56 (51, 60) 52 (47, 58) 55 (50, 59)
HRD+ n_trt 50 (50, 58) 54 (51, 64) 52 (50, 56) 52 (50, 66)
HRD+ n_control 78 (62, 88) 80 (68, 95) 65 (54, 78) 79 (61, 93)
HRD+ post_p 0.19 (0.07, 0.23) 0.16 (0.11, 0.23) 0.16 (0.11, 0.25) 0.12 (0.07, 0.29)
HRD+ order 2 (1, 2.5) 3 (2, 5.2) 3 (1.7, 4.6) 3 (1.4, 4.2)
TP53+ count 75 91 62 90
TP53+ time_stop 40 (28, 56) 33 (21, 50) 40 (30, 52) 39 (28, 54)
TP53+ n_trt 67 (52, 105) 64 (51, 101) 64 (51, 101) 74 (52, 104)
TP53+ n_control 138 (90, 204) 108 (68, 181) 138 (91, 186) 139 (86, 194)
TP53+ post_p 0.09 (0.01, 0.22) 0.12 (0.03, 0.24) 0.12 (0.03, 0.22) 0.11 (0.03, 0.21)
TP53+ order 1 (1, 3) 1 (1, 2) 1 (1, 3) 2 (1, 3)
TEfus+ count 41 52 52 40
TEfus+ time_stop 47 (34, 58) 43 (28, 59) 42 (31, 55) 46 (36, 56)
TEfus+ n_trt 66 (52, 117) 62 (50, 94) 60 (50, 86) 66 (54, 83)
TEfus+ n_control 141 (91, 194) 129 (65, 181) 125 (82, 175) 144 (103, 173)
TEfus+ post_p 0.1 (0.02, 0.24) 0.11 (0.02, 0.23) 0.11 (0.03, 0.22) 0.06 (0.01, 0.19)
TEfus+ order 2 (1, 4) 2 (1, 3) 2 (1, 3) 2 (1, 4)
PI3K+ count 56 64 49 81
PI3K+ time_stop 43 (28, 58) 45 (27, 55) 39 (31, 54) 36 (25, 51)
PI3K+ n_trt 62 (50, 100) 63 (50, 103) 61 (50, 107) 68 (53, 99)
PI3K+ n_control 134 (80, 202) 144 (76, 201) 127 (84, 188) 114 (67, 176)
PI3K+ post_p 0.1 (0.02, 0.21) 0.07 (0.03, 0.21) 0.06 (0.02, 0.2) 0.09 (0.02, 0.22)
PI3K+ order 2 (1, 4) 2 (1, 4) 2 (1, 3.2) 1 (1, 3)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17 17
all TC1 time 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39) 16 (10, 39)
all TC1 n 37 (25, 77) 9 (5, 16) 2 (0, 5) 10 (4, 28) 14 (7, 22) 7 (3, 25) 8 (4, 17) 4 (2, 10) 6 (1, 18) 0 (0, 0) 4 (1, 11) 1 (0, 4) 0 (0, 0) 1 (0, 5) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.61 (0.54, 0.74) 0.57 (0.55, 0.77) 0.53 (0.5, 0.55) 0.55 (0.52, 0.8) 0.57 (0.51, 0.75) 0.59 (0.51, 0.78) 0.54 (0.51, 0.85) 0.54 (0.5, 0.64) 0.53 (0.51, 0.72) NA (NA, NA) 0.54 (0.51, 0.66) 0.54 (0.51, 0.55) NA (NA, NA) 0.54 (0.52, 0.73) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.012 (0.004, 0.017) 0 (0, 0.015) 0 (0, 0.009) 0 (0, 0.016) 0 (0, 0.021) 0 (0, 0.015) 0 (0, 0.021) 0 (0, 0.013) 0 (0, 0.021) NA (NA, NA) 0 (0, 0.013) 0 (0, 0.01) 0 (0, 0) 0 (0, 0.016) NA (NA, NA) NA (NA, NA)
all TC2 count 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
all TC2 time 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37) 11 (9, 37)
all TC2 n 28 (17, 71) 4 (1, 15) 4 (2, 6) 6 (2, 22) 12 (8, 34) 8 (5, 21) 8 (6, 25) 4 (2, 12) 4 (0, 12) 0 (0, 0) 1 (0, 8) 0 (0, 1) 0 (0, 0) 1 (0, 4) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.57 (0.52, 0.69) 0.55 (0.51, 0.69) 0.54 (0.51, 0.65) 0.55 (0.52, 0.8) 0.58 (0.53, 0.68) 0.54 (0.51, 0.8) 0.55 (0.52, 0.78) 0.53 (0.52, 0.56) 0.54 (0.52, 0.56) NA (NA, NA) 0.54 (0.52, 0.76) 0.56 (0.51, 0.6) NA (NA, NA) 0.52 (0.5, 0.59) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.011 (0, 0.02) 0 (0, 0.012) 0 (0, 0.014) 0 (0, 0.015) 0.008 (0, 0.019) 0 (0, 0.015) 0 (0, 0.015) 0 (0, 0.014) 0.007 (0, 0.027) NA (NA, NA) 0 (0, 0.012) 0 (0, 0) 0 (0, 0) 0 (0, 0.018) NA (NA, NA) NA (NA, NA)
all TC3 count 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16 16
all TC3 time 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17) 14 (10, 17)
all TC3 n 17 (11, 33) 4 (1, 8) 1 (0, 2) 6 (3, 11) 7 (4, 12) 6 (2, 10) 4 (1, 10) 3 (2, 8) 7 (6, 12) 0 (0, 0) 7 (4, 10) 1 (0, 2) 0 (0, 1) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.57 (0.52, 0.77) 0.54 (0.51, 0.62) 0.52 (0.5, 0.55) 0.53 (0.5, 0.61) 0.53 (0.52, 0.58) 0.53 (0.51, 0.63) 0.52 (0.5, 0.59) 0.54 (0.51, 0.57) 0.54 (0.5, 0.6) NA (NA, NA) 0.55 (0.52, 0.62) 0.52 (0.51, 0.53) 0.52 (0.52, 0.52) 0.52 (0.51, 0.54) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.005 (0, 0.017) 0 (0, 0.015) 0 (0, 0.023) 0 (0, 0.007) 0 (0, 0.016) 0 (0, 0.009) 0 (0, 0.009) 0 (0, 0.008) 0 (0, 0.015) NA (NA, NA) 0 (0, 0) 0 (0, 0.11) 0 (0, 0) 0 (0, 0.061) NA (NA, NA) NA (NA, NA)
all TC4 count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
all TC4 time 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33) 16 (11, 33)
all TC4 n 22 (13, 77) 8 (2, 14) 2 (1, 4) 10 (5, 16) 10 (4, 18) 8 (5, 15) 5 (2, 18) 7 (3, 16) 4 (2, 14) 0 (0, 0) 3 (1, 7) 1 (0, 3) 0 (0, 1) 2 (0, 4) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.7 (0.56, 0.81) 0.55 (0.5, 0.6) 0.53 (0.51, 0.59) 0.57 (0.52, 0.63) 0.56 (0.51, 0.78) 0.57 (0.51, 0.66) 0.55 (0.51, 0.63) 0.55 (0.52, 0.65) 0.55 (0.52, 0.8) NA (NA, NA) 0.54 (0.5, 0.58) 0.53 (0.5, 0.55) 0.52 (0.52, 0.52) 0.52 (0.51, 0.56) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.006 (0, 0.017) 0 (0, 0.017) 0 (0, 0.006) 0 (0, 0.018) 0 (0, 0.018) 0.003 (0, 0.016) 0 (0, 0.018) 0 (0, 0.015) 0 (0, 0.012) NA (NA, NA) 0 (0, 0.011) 0 (0, 0.042) 0 (0, 19.453) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 16 16 16 16 16 16 16 16
HRD+ TC1 time 52 (48, 58) 52 (48, 58) 52 (48, 58) 52 (48, 58) 52 (48, 58) 52 (48, 58) 52 (48, 58) 52 (48, 58)
HRD+ TC1 n 28 (19, 36) 0 (0, 0) 16 (10, 27) 4 (2, 6) 0 (0, 1) 6 (2, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.79 (0.74, 0.94) NA (NA, NA) 0.76 (0.64, 0.91) 0.58 (0.51, 0.61) 0.51 (0.5, 0.52) 0.54 (0.51, 0.64) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.013 (0.009, 0.02) NA (NA, NA) 0.014 (0.007, 0.02) 0.013 (0, 0.024) 0 (0, 0.027) 0.011 (0, 0.023) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 16 16 16 16 16 16 16 16
HRD+ TC2 time 50 (45, 60) 50 (45, 60) 50 (45, 60) 50 (45, 60) 50 (45, 60) 50 (45, 60) 50 (45, 60) 50 (45, 60)
HRD+ TC2 n 28 (21, 34) 0 (0, 0) 15 (10, 23) 4 (1, 6) 0 (0, 2) 5 (3, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.86 (0.71, 0.95) NA (NA, NA) 0.78 (0.65, 0.95) 0.57 (0.53, 0.65) 0.56 (0.56, 0.56) 0.58 (0.52, 0.85) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.013 (0.008, 0.018) NA (NA, NA) 0.011 (0.005, 0.018) 0 (0, 0.014) 0 (0, 0.102) 0.014 (0.007, 0.023) NA (NA, NA) 0 (0, 0)
HRD+ TC3 count 12 12 12 12 12 12 12 12
HRD+ TC3 time 49 (44, 60) 49 (44, 60) 49 (44, 60) 49 (44, 60) 49 (44, 60) 49 (44, 60) 49 (44, 60) 49 (44, 60)
HRD+ TC3 n 26 (18, 33) 0 (0, 0) 18 (9, 21) 4 (3, 8) 0 (0, 2) 5 (2, 10) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.8 (0.71, 0.89) NA (NA, NA) 0.76 (0.6, 0.89) 0.56 (0.52, 0.77) 0.58 (0.53, 0.61) 0.6 (0.52, 0.72) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.015 (0.013, 0.018) 0 (0, 0) 0.018 (0.009, 0.022) 0.009 (0, 0.017) 0.008 (0, 0.039) 0.011 (0, 0.023) NA (NA, NA) 0 (0, 0)
HRD+ TC4 count 14 14 14 14 14 14 14 14
HRD+ TC4 time 56 (50, 59) 56 (50, 59) 56 (50, 59) 56 (50, 59) 56 (50, 59) 56 (50, 59) 56 (50, 59) 56 (50, 59)
HRD+ TC4 n 22 (16, 34) 0 (0, 0) 19 (15, 25) 5 (2, 9) 1 (0, 2) 5 (3, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.77 (0.71, 0.8) NA (NA, NA) 0.77 (0.7, 0.96) 0.58 (0.53, 0.74) 0.52 (0.51, 0.57) 0.6 (0.56, 0.72) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.015 (0.012, 0.02) NA (NA, NA) 0.015 (0.009, 0.021) 0.01 (0, 0.019) 0 (0, 0.063) 0.014 (0, 0.021) NA (NA, NA) 0 (0, 0)
TP53+ TC1 count 13 13 13 13 13 13 13 13
TP53+ TC1 time 28 (20, 40) 28 (20, 40) 28 (20, 40) 28 (20, 40) 28 (20, 40) 28 (20, 40) 28 (20, 40) 28 (20, 40)
TP53+ TC1 n 25 (21, 34) 13 (8, 20) 9 (7, 16) 9 (4, 19) 0 (0, 1) 1 (0, 4) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.82 (0.72, 0.89) 0.72 (0.53, 0.81) 0.63 (0.51, 0.73) 0.57 (0.54, 0.82) NA (NA, NA) 0.52 (0.51, 0.62) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.009 (0, 0.014) 0.009 (0.001, 0.017) 0.01 (0, 0.02) 0.006 (0, 0.011) 0 (0, 0.122) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 11 11 11 11 11 11 11 11
TP53+ TC2 time 44 (32, 51) 44 (32, 51) 44 (32, 51) 44 (32, 51) 44 (32, 51) 44 (32, 51) 44 (32, 51) 44 (32, 51)
TP53+ TC2 n 47 (28, 69) 18 (14, 28) 24 (16, 36) 15 (8, 24) 1 (0, 2) 3 (1, 4) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.83 (0.73, 0.91) 0.79 (0.7, 0.86) 0.77 (0.71, 0.92) 0.76 (0.6, 0.84) 0.54 (0.53, 0.58) 0.52 (0.5, 0.59) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.014 (0.01, 0.02) 0.013 (0.004, 0.021) 0.013 (0.01, 0.016) 0.013 (0.004, 0.016) 0 (0, 0.071) 0.016 (0, 0.058) NA (NA, NA) 0.023 (0.023, 0.023)
TP53+ TC3 count 21 21 21 21 21 21 21 21
TP53+ TC3 time 29 (23, 52) 29 (23, 52) 29 (23, 52) 29 (23, 52) 29 (23, 52) 29 (23, 52) 29 (23, 52) 29 (23, 52)
TP53+ TC3 n 23 (16, 34) 15 (10, 27) 12 (7, 27) 7 (5, 11) 0 (0, 2) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.75 (0.71, 0.86) 0.74 (0.57, 0.87) 0.71 (0.54, 0.82) 0.6 (0.51, 0.79) 0.55 (0.53, 0.56) 0.54 (0.51, 0.59) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.012 (0.005, 0.018) 0.012 (0, 0.018) 0.009 (0, 0.018) 0.014 (0, 0.022) 0 (0, 0.119) 0 (0, 0.027) NA (NA, NA) 0 (0, 0)
TP53+ TC4 count 11 11 11 11 11 11 11 11
TP53+ TC4 time 37 (21, 52) 37 (21, 52) 37 (21, 52) 37 (21, 52) 37 (21, 52) 37 (21, 52) 37 (21, 52) 37 (21, 52)
TP53+ TC4 n 30 (13, 38) 23 (16, 27) 13 (7, 27) 14 (9, 22) 0 (0, 1) 3 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.79 (0.7, 0.9) 0.76 (0.71, 0.83) 0.75 (0.55, 0.92) 0.75 (0.54, 0.94) 0.51 (0.51, 0.51) 0.54 (0.52, 0.61) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.013 (0.007, 0.015) 0.011 (0.007, 0.015) 0.014 (0, 0.016) 0.014 (0.009, 0.017) 0 (0, 0.126) 0 (0, 0.026) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 19 19 19 19 19 19 19 19
TEfus+ TC1 time 31 (26, 48) 31 (26, 48) 31 (26, 48) 31 (26, 48) 31 (26, 48) 31 (26, 48) 31 (26, 48) 31 (26, 48)
TEfus+ TC1 n 4 (1, 6) 21 (19, 40) 15 (9, 25) 10 (5, 20) 8 (6, 11) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.55 (0.51, 0.68) 0.77 (0.72, 0.95) 0.75 (0.54, 0.89) 0.66 (0.51, 0.76) 0.61 (0.52, 0.71) 0.55 (0.52, 0.63) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.005 (0, 0.019) 0.009 (0.005, 0.014) 0.009 (0.004, 0.02) 0.011 (0.007, 0.019) 0.009 (0, 0.023) 0 (0, 0.02) NA (NA, NA) 0 (0, 0)
TEfus+ TC2 count 5 5 5 5 5 5 5 5
TEfus+ TC2 time 29 (20, 49) 29 (20, 49) 29 (20, 49) 29 (20, 49) 29 (20, 49) 29 (20, 49) 29 (20, 49) 29 (20, 49)
TEfus+ TC2 n 4 (1, 9) 21 (20, 41) 18 (13, 26) 8 (8, 15) 10 (6, 11) 1 (0, 4) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.54 (0.52, 0.61) 0.83 (0.79, 0.93) 0.72 (0.71, 0.75) 0.57 (0.51, 0.72) 0.55 (0.53, 0.67) 0.72 (0.55, 0.9) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.013 (0, 0.015) 0.009 (0.004, 0.02) 0.01 (0.006, 0.015) 0.011 (0.004, 0.021) 0.016 (0.009, 0.022) 0 (0, 0.005) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 count 13 13 13 13 13 13 13 13
TEfus+ TC3 time 32 (27, 48) 32 (27, 48) 32 (27, 48) 32 (27, 48) 32 (27, 48) 32 (27, 48) 32 (27, 48) 32 (27, 48)
TEfus+ TC3 n 5 (1, 8) 20 (17, 33) 12 (8, 20) 10 (7, 16) 10 (7, 17) 3 (1, 7) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.57 (0.52, 0.63) 0.78 (0.72, 0.89) 0.81 (0.53, 0.89) 0.69 (0.52, 0.76) 0.63 (0.52, 0.81) 0.54 (0.51, 0.58) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0 (0, 0.015) 0.009 (0.001, 0.018) 0.008 (0.001, 0.018) 0.011 (0, 0.018) 0.016 (0.007, 0.025) 0 (0, 0.015) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 9 9 9 9 9 9 9 9
TEfus+ TC4 time 32 (29, 53) 32 (29, 53) 32 (29, 53) 32 (29, 53) 32 (29, 53) 32 (29, 53) 32 (29, 53) 32 (29, 53)
TEfus+ TC4 n 4 (2, 10) 20 (19, 31) 19 (7, 27) 13 (8, 18) 8 (3, 17) 2 (1, 7) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.57 (0.53, 0.79) 0.74 (0.72, 0.79) 0.74 (0.64, 0.89) 0.71 (0.53, 0.77) 0.62 (0.54, 0.83) 0.53 (0.51, 0.67) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0 (0, 0.013) 0.012 (0.006, 0.014) 0.01 (0.005, 0.014) 0.014 (0.012, 0.017) 0.01 (0, 0.019) 0.015 (0, 0.061) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 11 11 11 11 11 11 11 11
PI3K+ TC1 time 31 (25, 48) 31 (25, 48) 31 (25, 48) 31 (25, 48) 31 (25, 48) 31 (25, 48) 31 (25, 48) 31 (25, 48)
PI3K+ TC1 n 18 (9, 21) 22 (16, 47) 14 (9, 28) 7 (4, 12) 0 (0, 0) 3 (1, 5) 2 (0, 5) 0 (0, 0)
PI3K+ TC1 post_p 0.77 (0.65, 0.82) 0.8 (0.73, 0.92) 0.72 (0.59, 0.82) 0.6 (0.52, 0.73) NA (NA, NA) 0.53 (0.51, 0.66) 0.56 (0.5, 0.69) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.01 (0, 0.018) 0.011 (0, 0.017) 0.012 (0.005, 0.016) 0.013 (0.007, 0.023) NA (NA, NA) 0 (0, 0.033) 0 (0, 0.016) NA (NA, NA)
PI3K+ TC2 count 12 12 12 12 12 12 12 12
PI3K+ TC2 time 38 (30, 52) 38 (30, 52) 38 (30, 52) 38 (30, 52) 38 (30, 52) 38 (30, 52) 38 (30, 52) 38 (30, 52)
PI3K+ TC2 n 14 (6, 27) 24 (17, 36) 17 (10, 28) 10 (6, 20) 0 (0, 0) 2 (0, 3) 2 (1, 5) 0 (0, 0)
PI3K+ TC2 post_p 0.72 (0.55, 0.8) 0.8 (0.74, 0.95) 0.76 (0.65, 0.85) 0.64 (0.55, 0.75) NA (NA, NA) 0.54 (0.5, 0.57) 0.54 (0.51, 0.7) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.012 (0, 0.016) 0.013 (0.008, 0.022) 0.011 (0.008, 0.016) 0.013 (0.009, 0.017) NA (NA, NA) 0 (0, 0.028) 0 (0, 0.014) NA (NA, NA)
PI3K+ TC3 count 9 9 9 9 9 9 9 9
PI3K+ TC3 time 30 (26, 48) 30 (26, 48) 30 (26, 48) 30 (26, 48) 30 (26, 48) 30 (26, 48) 30 (26, 48) 30 (26, 48)
PI3K+ TC3 n 11 (8, 21) 18 (9, 41) 17 (14, 30) 13 (9, 26) 0 (0, 0) 2 (0, 3) 4 (1, 7) 0 (0, 0)
PI3K+ TC3 post_p 0.79 (0.53, 0.88) 0.76 (0.57, 0.84) 0.72 (0.67, 0.79) 0.78 (0.54, 0.93) NA (NA, NA) 0.52 (0.51, 0.53) 0.56 (0.51, 0.59) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.006 (0, 0.018) 0.013 (0, 0.019) 0.011 (0.007, 0.022) 0.012 (0.004, 0.016) NA (NA, NA) 0 (0, 0.018) 0 (0, 0.014) NA (NA, NA)
PI3K+ TC4 count 4 4 4 4 4 4 4 4
PI3K+ TC4 time 34 (22, 42) 34 (22, 42) 34 (22, 42) 34 (22, 42) 34 (22, 42) 34 (22, 42) 34 (22, 42) 34 (22, 42)
PI3K+ TC4 n 13 (10, 20) 32 (28, 46) 30 (17, 37) 7 (6, 13) 0 (0, 0) 2 (1, 3) 2 (1, 4) 0 (0, 0)
PI3K+ TC4 post_p 0.7 (0.56, 0.87) 0.81 (0.8, 0.83) 0.74 (0.71, 0.75) 0.63 (0.51, 0.76) NA (NA, NA) 0.52 (0.51, 0.57) 0.53 (0.52, 0.55) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.013 (0.01, 0.015) 0.011 (0.008, 0.016) 0.008 (0.007, 0.013) 0.013 (0.003, 0.024) NA (NA, NA) 0 (0, 0.009) 0 (0, 0.014) NA (NA, NA)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
all TC1 time 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53) 48 (31, 53)
all TC1 n 44 (36, 56) 11 (7, 18) 5 (4, 7) 11 (9, 22) 13 (10, 25) 14 (8, 24) 12 (7, 21) 10 (9, 16) 14 (7, 21) 0 (0, 0) 7 (4, 14) 2 (1, 3) 0 (0, 1) 3 (1, 4) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.27 (0.04, 0.49) 0.27 (0.17, 0.39) 0.4 (0.21, 0.48) 0.34 (0.11, 0.47) 0.24 (0.04, 0.44) 0.19 (0.06, 0.42) 0.27 (0.19, 0.39) 0.27 (0.16, 0.34) 0.36 (0.25, 0.45) NA (NA, NA) 0.38 (0.18, 0.48) 0.44 (0.25, 0.47) 0.45 (0.45, 0.45) 0.45 (0.38, 0.48) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.025 (0.021, 0.031) 0.032 (0.023, 0.039) 0.031 (0.023, 0.043) 0.029 (0.017, 0.038) 0.027 (0.018, 0.05) 0.029 (0.019, 0.039) 0.031 (0.021, 0.035) 0.029 (0.019, 0.049) 0.024 (0.02, 0.03) NA (NA, NA) 0.03 (0.027, 0.048) 0.047 (0.013, 0.072) 0.036 (0, 0.084) 0.039 (0.017, 0.048) NA (NA, NA) NA (NA, NA)
all TC2 count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
all TC2 time 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46) 43 (24, 46)
all TC2 n 29 (20, 29) 7 (6, 17) 4 (1, 5) 24 (14, 43) 12 (10, 14) 15 (10, 20) 10 (9, 13) 7 (6, 10) 12 (8, 15) 0 (0, 0) 11 (7, 12) 2 (0, 4) 1 (0, 1) 1 (0, 6) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.22 (0.14, 0.26) 0.31 (0.22, 0.4) 0.38 (0.36, 0.39) 0.45 (0.38, 0.46) 0.11 (0.03, 0.4) 0.4 (0.34, 0.42) 0.27 (0.22, 0.33) 0.22 (0.14, 0.32) 0.34 (0.31, 0.42) NA (NA, NA) 0.45 (0.4, 0.49) 0.45 (0.42, 0.48) 0.45 (0.45, 0.45) 0.35 (0.3, 0.41) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.026 (0.026, 0.029) 0.022 (0.022, 0.048) 0.038 (0.034, 0.042) 0.017 (0.012, 0.018) 0.038 (0.022, 0.043) 0.023 (0.018, 0.03) 0.03 (0.028, 0.034) 0.041 (0.034, 0.046) 0.031 (0.022, 0.046) NA (NA, NA) 0.017 (0.016, 0.023) 0.067 (0.026, 0.109) 0 (0, 0) 0.039 (0.036, 0.042) NA (NA, NA) NA (NA, NA)
all TC3 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC3 time 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52) 38 (36, 52)
all TC3 n 41 (21, 83) 10 (6, 13) 4 (2, 10) 20 (17, 30) 20 (12, 25) 10 (8, 14) 9 (5, 22) 13 (8, 28) 13 (10, 15) 0 (0, 0) 13 (6, 14) 2 (0, 5) 0 (0, 1) 2 (2, 3) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.35 (0.1, 0.43) 0.34 (0.21, 0.39) 0.48 (0.47, 0.49) 0.45 (0.31, 0.48) 0.4 (0.11, 0.42) 0.2 (0.07, 0.37) 0.33 (0.09, 0.41) 0.16 (0.11, 0.38) 0.29 (0.24, 0.46) NA (NA, NA) 0.23 (0.1, 0.35) 0.43 (0.42, 0.45) 0.5 (0.5, 0.5) 0.48 (0.48, 0.49) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.021 (0.02, 0.033) 0.027 (0.026, 0.07) 0.023 (0.015, 0.04) 0.024 (0.019, 0.025) 0.029 (0.023, 0.035) 0.035 (0.025, 0.049) 0.023 (0.02, 0.083) 0.035 (0.025, 0.049) 0.026 (0.022, 0.032) NA (NA, NA) 0.027 (0.022, 0.031) 0.02 (0.018, 0.127) 0 (0, 0) 0.041 (0.005, 0.044) NA (NA, NA) NA (NA, NA)
all TC4 count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
all TC4 time 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49) 48 (29, 49)
all TC4 n 32 (21, 90) 14 (9, 29) 4 (3, 9) 14 (12, 37) 15 (10, 32) 11 (9, 29) 6 (4, 12) 9 (6, 16) 15 (7, 30) 0 (0, 0) 10 (5, 10) 4 (2, 6) 0 (0, 2) 3 (0, 4) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.21 (0.05, 0.45) 0.42 (0.25, 0.5) 0.48 (0.43, 0.49) 0.33 (0.18, 0.49) 0.37 (0.25, 0.41) 0.22 (0.09, 0.42) 0.45 (0.33, 0.49) 0.34 (0.12, 0.39) 0.36 (0.2, 0.42) NA (NA, NA) 0.46 (0.18, 0.46) 0.47 (0.33, 0.48) NA (NA, NA) 0.44 (0.35, 0.47) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.022 (0.019, 0.036) 0.018 (0.017, 0.028) 0.028 (0.018, 0.035) 0.018 (0.016, 0.029) 0.027 (0.022, 0.035) 0.031 (0.021, 0.049) 0.022 (0.02, 0.046) 0.038 (0.026, 0.047) 0.021 (0.018, 0.051) NA (NA, NA) 0.03 (0.024, 0.042) 0.024 (0.015, 0.053) 0 (0, 0) 0.057 (0.016, 0.104) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 6 6 6 6 6 6 6 6
HRD+ TC1 time 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60) 58 (54, 60)
HRD+ TC1 n 20 (14, 36) 0 (0, 0) 22 (12, 26) 4 (2, 4) 0 (0, 0) 6 (3, 10) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.35 (0.11, 0.47) NA (NA, NA) 0.37 (0.2, 0.47) 0.43 (0.37, 0.45) 0.44 (0.44, 0.44) 0.47 (0.33, 0.5) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.025 (0.019, 0.046) NA (NA, NA) 0.027 (0.023, 0.042) 0.035 (0.021, 0.042) 0.176 (0.176, 0.176) 0.024 (0.018, 0.049) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 8 8 8 8 8 8 8 8
HRD+ TC2 time 56 (51, 60) 56 (51, 60) 56 (51, 60) 56 (51, 60) 56 (51, 60) 56 (51, 60) 56 (51, 60) 56 (51, 60)
HRD+ TC2 n 36 (21, 42) 0 (0, 0) 14 (7, 31) 3 (0, 6) 0 (0, 1) 4 (1, 5) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.36 (0.3, 0.47) NA (NA, NA) 0.29 (0.23, 0.4) 0.42 (0.21, 0.49) 0.45 (0.43, 0.47) 0.42 (0.28, 0.48) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.022 (0.017, 0.027) NA (NA, NA) 0.026 (0.018, 0.032) 0.033 (0.017, 0.085) 0.031 (0, 0.475) 0.033 (0.015, 0.076) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 8 8 8 8 8 8 8 8
HRD+ TC3 time 52 (47, 58) 52 (47, 58) 52 (47, 58) 52 (47, 58) 52 (47, 58) 52 (47, 58) 52 (47, 58) 52 (47, 58)
HRD+ TC3 n 30 (22, 36) 0 (0, 0) 14 (11, 22) 4 (2, 6) 0 (0, 2) 2 (1, 6) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.42 (0.36, 0.45) NA (NA, NA) 0.32 (0.16, 0.46) 0.42 (0.25, 0.48) 0.45 (0.43, 0.48) 0.41 (0.29, 0.45) NA (NA, NA) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.02 (0.017, 0.025) NA (NA, NA) 0.024 (0.016, 0.032) 0.03 (0.018, 0.045) 0.018 (0.005, 0.065) 0.06 (0.027, 0.089) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 5 5 5 5 5 5 5 5
HRD+ TC4 time 55 (50, 59) 55 (50, 59) 55 (50, 59) 55 (50, 59) 55 (50, 59) 55 (50, 59) 55 (50, 59) 55 (50, 59)
HRD+ TC4 n 27 (21, 36) 0 (0, 0) 18 (13, 19) 4 (1, 7) 1 (0, 2) 8 (2, 11) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.34 (0.27, 0.43) NA (NA, NA) 0.34 (0.16, 0.47) 0.44 (0.34, 0.45) 0.46 (0.46, 0.46) 0.47 (0.26, 0.48) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.022 (0.017, 0.024) NA (NA, NA) 0.019 (0.017, 0.025) 0.027 (0.021, 0.093) 0.049 (0.01, 0.054) 0.03 (0.017, 0.052) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 75 75 75 75 75 75 75 75
TP53+ TC1 time 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56) 40 (28, 56)
TP53+ TC1 n 20 (11, 51) 15 (8, 31) 13 (8, 25) 11 (7, 19) 0 (0, 2) 3 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.33 (0.08, 0.45) 0.32 (0.06, 0.47) 0.35 (0.14, 0.46) 0.38 (0.17, 0.47) 0.47 (0.43, 0.49) 0.45 (0.37, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.024 (0.019, 0.041) 0.025 (0.016, 0.045) 0.026 (0.019, 0.037) 0.026 (0.018, 0.045) 0 (0, 0.073) 0.026 (0, 0.049) NA (NA, NA) 0.044 (0.009, 0.054)
TP53+ TC2 count 91 91 91 91 91 91 91 91
TP53+ TC2 time 33 (21, 50) 33 (21, 50) 33 (21, 50) 33 (21, 50) 33 (21, 50) 33 (21, 50) 33 (21, 50) 33 (21, 50)
TP53+ TC2 n 21 (13, 34) 13 (8, 27) 14 (9, 24) 11 (6, 21) 0 (0, 1) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.31 (0.11, 0.47) 0.39 (0.19, 0.49) 0.34 (0.16, 0.47) 0.39 (0.15, 0.48) 0.48 (0.45, 0.5) 0.44 (0.39, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.023 (0.017, 0.036) 0.024 (0.017, 0.037) 0.024 (0.017, 0.035) 0.026 (0.016, 0.041) 0 (0, 0.071) 0.031 (0, 0.1) NA (NA, NA) 0 (0, 0)
TP53+ TC3 count 62 62 62 62 62 62 62 62
TP53+ TC3 time 40 (30, 52) 40 (30, 52) 40 (30, 52) 40 (30, 52) 40 (30, 52) 40 (30, 52) 40 (30, 52) 40 (30, 52)
TP53+ TC3 n 22 (11, 40) 15 (8, 27) 13 (7, 20) 10 (6, 17) 1 (0, 2) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.34 (0.18, 0.48) 0.32 (0.13, 0.45) 0.38 (0.14, 0.5) 0.35 (0.16, 0.48) 0.47 (0.43, 0.5) 0.44 (0.37, 0.48) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.023 (0.018, 0.034) 0.025 (0.017, 0.042) 0.025 (0.018, 0.038) 0.025 (0.016, 0.046) 0.021 (0, 0.083) 0.032 (0.009, 0.11) 0 (0, 0) 0.181 (0.036, 0.327)
TP53+ TC4 count 90 90 90 90 90 90 90 90
TP53+ TC4 time 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54) 39 (28, 54)
TP53+ TC4 n 25 (13, 45) 15 (9, 26) 13 (7, 28) 12 (6, 20) 0 (0, 1) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.39 (0.16, 0.49) 0.31 (0.09, 0.47) 0.38 (0.19, 0.48) 0.36 (0.16, 0.48) 0.46 (0.41, 0.49) 0.43 (0.31, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.022 (0.017, 0.033) 0.024 (0.017, 0.042) 0.025 (0.018, 0.037) 0.025 (0.017, 0.035) 0 (0, 0.069) 0.028 (0.01, 0.072) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 count 41 41 41 41 41 41 41 41
TEfus+ TC1 time 47 (34, 58) 47 (34, 58) 47 (34, 58) 47 (34, 58) 47 (34, 58) 47 (34, 58) 47 (34, 58) 47 (34, 58)
TEfus+ TC1 n 5 (3, 8) 20 (10, 53) 17 (8, 30) 13 (8, 21) 9 (4, 22) 2 (0, 4) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.41 (0.23, 0.48) 0.36 (0.13, 0.46) 0.33 (0.14, 0.44) 0.38 (0.23, 0.48) 0.4 (0.23, 0.49) 0.44 (0.33, 0.5) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.032 (0.018, 0.053) 0.022 (0.018, 0.032) 0.027 (0.019, 0.04) 0.025 (0.017, 0.034) 0.027 (0.018, 0.039) 0.027 (0, 0.109) NA (NA, NA) 0 (0, 0)
TEfus+ TC2 count 52 52 52 52 52 52 52 52
TEfus+ TC2 time 43 (28, 59) 43 (28, 59) 43 (28, 59) 43 (28, 59) 43 (28, 59) 43 (28, 59) 43 (28, 59) 43 (28, 59)
TEfus+ TC2 n 5 (3, 11) 18 (10, 34) 14 (8, 24) 11 (7, 20) 8 (4, 16) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.42 (0.23, 0.47) 0.34 (0.11, 0.47) 0.34 (0.08, 0.47) 0.32 (0.1, 0.48) 0.42 (0.19, 0.49) 0.46 (0.36, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.028 (0.014, 0.045) 0.023 (0.018, 0.036) 0.026 (0.016, 0.042) 0.028 (0.017, 0.045) 0.024 (0.016, 0.048) 0.027 (0, 0.106) NA (NA, NA) 0.469 (0.469, 0.469)
TEfus+ TC3 count 52 52 52 52 52 52 52 52
TEfus+ TC3 time 42 (31, 55) 42 (31, 55) 42 (31, 55) 42 (31, 55) 42 (31, 55) 42 (31, 55) 42 (31, 55) 42 (31, 55)
TEfus+ TC3 n 4 (2, 8) 18 (10, 31) 13 (7, 25) 12 (6, 18) 10 (6, 18) 3 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.44 (0.33, 0.49) 0.36 (0.19, 0.48) 0.36 (0.12, 0.48) 0.36 (0.13, 0.48) 0.28 (0.13, 0.47) 0.45 (0.37, 0.48) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.03 (0.017, 0.075) 0.025 (0.018, 0.035) 0.025 (0.018, 0.04) 0.025 (0.017, 0.048) 0.028 (0.018, 0.046) 0.03 (0.014, 0.082) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 40 40 40 40 40 40 40 40
TEfus+ TC4 time 46 (36, 56) 46 (36, 56) 46 (36, 56) 46 (36, 56) 46 (36, 56) 46 (36, 56) 46 (36, 56) 46 (36, 56)
TEfus+ TC4 n 5 (1, 6) 20 (13, 35) 14 (8, 30) 12 (6, 22) 8 (6, 15) 2 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.43 (0.24, 0.49) 0.27 (0.07, 0.47) 0.37 (0.13, 0.49) 0.31 (0.18, 0.45) 0.37 (0.1, 0.49) 0.44 (0.35, 0.48) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.032 (0.015, 0.16) 0.024 (0.016, 0.038) 0.025 (0.018, 0.041) 0.025 (0.018, 0.037) 0.027 (0.02, 0.047) 0.032 (0.016, 0.082) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 56 56 56 56 56 56 56 56
PI3K+ TC1 time 43 (28, 58) 43 (28, 58) 43 (28, 58) 43 (28, 58) 43 (28, 58) 43 (28, 58) 43 (28, 58) 43 (28, 58)
PI3K+ TC1 n 14 (8, 25) 16 (9, 31) 15 (10, 35) 10 (6, 19) 0 (0, 0) 2 (0, 4) 3 (1, 6) 0 (0, 0)
PI3K+ TC1 post_p 0.37 (0.16, 0.48) 0.37 (0.2, 0.49) 0.37 (0.12, 0.46) 0.34 (0.12, 0.47) NA (NA, NA) 0.44 (0.33, 0.49) 0.46 (0.34, 0.49) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.026 (0.019, 0.04) 0.023 (0.018, 0.033) 0.023 (0.018, 0.036) 0.028 (0.018, 0.064) NA (NA, NA) 0.041 (0, 0.097) 0.029 (0.013, 0.077) 0 (0, 0.045)
PI3K+ TC2 count 64 64 64 64 64 64 64 64
PI3K+ TC2 time 45 (27, 55) 45 (27, 55) 45 (27, 55) 45 (27, 55) 45 (27, 55) 45 (27, 55) 45 (27, 55) 45 (27, 55)
PI3K+ TC2 n 11 (7, 26) 17 (10, 37) 14 (9, 28) 11 (6, 24) 0 (0, 0) 3 (0, 6) 3 (1, 7) 0 (0, 0)
PI3K+ TC2 post_p 0.34 (0.1, 0.48) 0.33 (0.11, 0.45) 0.33 (0.11, 0.48) 0.35 (0.09, 0.47) NA (NA, NA) 0.44 (0.36, 0.49) 0.44 (0.32, 0.49) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.026 (0.018, 0.043) 0.025 (0.017, 0.034) 0.024 (0.017, 0.04) 0.026 (0.018, 0.042) NA (NA, NA) 0.025 (0.013, 0.105) 0.028 (0.012, 0.095) NA (NA, NA)
PI3K+ TC3 count 49 49 49 49 49 49 49 49
PI3K+ TC3 time 39 (31, 54) 39 (31, 54) 39 (31, 54) 39 (31, 54) 39 (31, 54) 39 (31, 54) 39 (31, 54) 39 (31, 54)
PI3K+ TC3 n 12 (5, 26) 19 (10, 33) 12 (8, 26) 11 (6, 20) 0 (0, 0) 3 (1, 5) 3 (2, 6) 0 (0, 0)
PI3K+ TC3 post_p 0.34 (0.2, 0.45) 0.35 (0.16, 0.47) 0.33 (0.12, 0.47) 0.35 (0.12, 0.48) NA (NA, NA) 0.44 (0.36, 0.49) 0.44 (0.35, 0.48) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.026 (0.019, 0.046) 0.024 (0.018, 0.03) 0.025 (0.017, 0.04) 0.025 (0.018, 0.043) NA (NA, NA) 0.031 (0.015, 0.09) 0.031 (0.012, 0.068) 0 (0, 0)
PI3K+ TC4 count 81 81 81 81 81 81 81 81
PI3K+ TC4 time 36 (25, 51) 36 (25, 51) 36 (25, 51) 36 (25, 51) 36 (25, 51) 36 (25, 51) 36 (25, 51) 36 (25, 51)
PI3K+ TC4 n 13 (8, 25) 18 (12, 32) 16 (10, 29) 12 (6, 20) 0 (0, 0) 2 (0, 5) 4 (1, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.32 (0.13, 0.46) 0.36 (0.14, 0.47) 0.35 (0.13, 0.48) 0.37 (0.19, 0.47) NA (NA, NA) 0.46 (0.37, 0.5) 0.43 (0.31, 0.49) NA (NA, NA)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.026 (0.017, 0.038) 0.024 (0.017, 0.033) 0.023 (0.017, 0.037) 0.023 (0.017, 0.042) NA (NA, NA) 0.032 (0, 0.088) 0.027 (0.013, 0.083) 0 (0, 0)