Treatments equally effective across the biomarker signatures
| signature | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| all | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| all | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| HRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| HRD+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| HRD+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TP53+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| TP53+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| TEfus+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| TEfus+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| PI3K+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| PI3K+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| PI3K+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —- | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| —+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| —+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| —+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –+- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –+- | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| –++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| –++ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| –++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+– | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+– | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+-+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+-+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -++- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -++- | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| -+++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| -+++ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| -+++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +— | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +— | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +— | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +–+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +–+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +–+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-+- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-+- | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +-+- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +-++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +-++ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +-++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++– | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++– | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| ++– | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++-+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++-+ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| ++-+ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| +++- | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| +++- | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| +++- | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
| ++++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 |
| ++++ | summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 |
| ++++ | effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
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| Characteristics | Overall | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| Error signature | 0.4 | 0.134 | 0.096 | 0.13 | 0.104 |
| Error subgroup | 0.4 | 0.134 | 0.096 | 0.13 | 0.104 |
| Power signature | 0.0 | 0.000 | 0.000 | 0.00 | 0.000 |
| Power subgroup | 0.0 | 0.000 | 0.000 | 0.00 | 0.000 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 17 | 10 | 16 | 18 |
| all | futility | 0 | 8 | 3 | 5 | 5 |
| all | max_n | 0 | 0 | 0 | 0 | 0 |
| all | n | 603 (554, 657) | 288 (202, 392) | 308 (208, 403) | 294 (204, 394) | 300 (207, 397) |
| all | n_unique | 603 (554, 657) | 288 (202, 392) | 308 (208, 403) | 294 (204, 394) | 300 (207, 397) |
| all | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) |
| all | time_stop | NA (NA, NA) | 25 (11, 52) | 12 (9, 43) | 15 (11, 38) | 17 (11, 48) |
| all | post_p | NA (NA, NA) | 0.48 (0.08, 0.89) | 0.49 (0.09, 0.88) | 0.49 (0.1, 0.89) | 0.46 (0.09, 0.9) |
| all | rate | 0.021 (0.019, 0.022) | 0.022 (0.019, 0.024) | 0.021 (0.019, 0.024) | 0.021 (0.019, 0.024) | 0.021 (0.019, 0.024) |
| HRD+ | graduation | 0 | 16 | 16 | 12 | 14 |
| HRD+ | futility | 0 | 6 | 8 | 8 | 5 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 82 (68, 96) | 42 (26, 62) | 44 (27, 60) | 47 (33, 65) | 43 (26, 61) |
| HRD+ | n_unique | 82 (68, 96) | 42 (26, 62) | 44 (27, 60) | 47 (33, 65) | 43 (26, 61) |
| HRD+ | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) |
| HRD+ | time_stop | NA (NA, NA) | 56 (48, 59) | 53 (46, 60) | 50 (46, 60) | 55 (50, 59) |
| HRD+ | post_p | NA (NA, NA) | 0.52 (0.11, 0.87) | 0.49 (0.13, 0.87) | 0.5 (0.13, 0.87) | 0.52 (0.11, 0.88) |
| HRD+ | rate | 0.021 (0.017, 0.025) | 0.021 (0.016, 0.03) | 0.021 (0.016, 0.029) | 0.022 (0.017, 0.028) | 0.021 (0.016, 0.029) |
| TP53+ | graduation | 0 | 13 | 11 | 21 | 11 |
| TP53+ | futility | 0 | 75 | 91 | 62 | 90 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 225 (196, 256) | 110 (59, 159) | 117 (62, 164) | 110 (58, 161) | 111 (60, 156) |
| TP53+ | n_unique | 225 (196, 256) | 110 (59, 159) | 117 (62, 164) | 110 (58, 161) | 111 (60, 156) |
| TP53+ | time_trial | 60 (60, 60) | 60 (42, 60) | 60 (35, 60) | 60 (41, 60) | 60 (39, 60) |
| TP53+ | time_stop | NA (NA, NA) | 39 (27, 55) | 36 (21, 51) | 38 (26, 52) | 39 (27, 54) |
| TP53+ | post_p | NA (NA, NA) | 0.47 (0.11, 0.87) | 0.47 (0.09, 0.9) | 0.53 (0.11, 0.92) | 0.49 (0.1, 0.9) |
| TP53+ | rate | 0.021 (0.018, 0.023) | 0.021 (0.018, 0.026) | 0.022 (0.018, 0.027) | 0.021 (0.017, 0.026) | 0.021 (0.018, 0.026) |
| TEfus+ | graduation | 0 | 19 | 5 | 13 | 9 |
| TEfus+ | futility | 0 | 41 | 52 | 52 | 40 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 192 (170, 217) | 97 (58, 134) | 100 (58, 139) | 97 (58, 136) | 97 (60, 139) |
| TEfus+ | n_unique | 192 (170, 217) | 97 (58, 134) | 100 (58, 139) | 97 (58, 136) | 97 (60, 139) |
| TEfus+ | time_trial | 60 (60, 60) | 60 (54, 60) | 60 (57, 60) | 60 (48, 60) | 60 (60, 60) |
| TEfus+ | time_stop | NA (NA, NA) | 42 (29, 57) | 42 (25, 58) | 40 (29, 54) | 44 (31, 56) |
| TEfus+ | post_p | NA (NA, NA) | 0.48 (0.09, 0.87) | 0.46 (0.09, 0.88) | 0.49 (0.11, 0.89) | 0.49 (0.1, 0.89) |
| TEfus+ | rate | 0.021 (0.018, 0.024) | 0.021 (0.017, 0.026) | 0.022 (0.018, 0.027) | 0.021 (0.018, 0.026) | 0.021 (0.018, 0.026) |
| PI3K+ | graduation | 0 | 11 | 12 | 9 | 4 |
| PI3K+ | futility | 0 | 56 | 64 | 49 | 81 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 208 (183, 236) | 104 (60, 145) | 108 (59, 148) | 106 (59, 146) | 108 (60, 154) |
| PI3K+ | n_unique | 208 (183, 236) | 104 (60, 145) | 108 (59, 148) | 106 (59, 146) | 108 (60, 154) |
| PI3K+ | time_trial | 60 (60, 60) | 60 (51, 60) | 60 (47, 60) | 60 (52, 60) | 60 (38, 60) |
| PI3K+ | time_stop | NA (NA, NA) | 42 (28, 56) | 44 (28, 54) | 37 (30, 53) | 36 (24, 51) |
| PI3K+ | post_p | NA (NA, NA) | 0.46 (0.07, 0.88) | 0.45 (0.08, 0.87) | 0.51 (0.1, 0.87) | 0.49 (0.07, 0.87) |
| PI3K+ | rate | 0.02 (0.018, 0.023) | 0.021 (0.018, 0.026) | 0.022 (0.018, 0.026) | 0.021 (0.017, 0.026) | 0.022 (0.018, 0.027) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 17 | 10 | 16 | 18 |
| —- | futility | 0 | 8 | 3 | 5 | 5 |
| —- | max_n | 0 | 0 | 0 | 0 | 0 |
| —- | n | 188 (156, 222) | 73 (30, 160) | 88 (29, 166) | 71 (23, 157) | 85 (25, 163) |
| —- | n_unique | 188 (156, 222) | 73 (30, 160) | 88 (29, 166) | 71 (23, 157) | 85 (25, 163) |
| —- | post_p | NA (NA, NA) | 0.42 (0.09, 0.87) | 0.5 (0.08, 0.88) | 0.43 (0.07, 0.86) | 0.45 (0.08, 0.87) |
| —- | rate | 0.021 (0.018, 0.024) | 0.022 (0.018, 0.029) | 0.022 (0.017, 0.029) | 0.022 (0.017, 0.03) | 0.021 (0.017, 0.029) |
| —+ | graduation | 0 | 26 | 21 | 25 | 22 |
| —+ | futility | 0 | 57 | 65 | 49 | 82 |
| —+ | max_n | 0 | 0 | 0 | 0 | 0 |
| —+ | n | 42 (31, 54) | 21 (10, 39) | 18 (8, 38) | 20 (7, 39) | 19 (9, 39) |
| —+ | n_unique | 42 (31, 54) | 21 (10, 39) | 18 (8, 38) | 20 (7, 39) | 19 (9, 39) |
| —+ | post_p | NA (NA, NA) | 0.49 (0.14, 0.85) | 0.43 (0.13, 0.85) | 0.49 (0.11, 0.86) | 0.47 (0.13, 0.83) |
| —+ | rate | 0.021 (0.015, 0.028) | 0.022 (0.015, 0.034) | 0.023 (0.015, 0.038) | 0.021 (0.014, 0.036) | 0.022 (0.015, 0.035) |
| –+- | graduation | 0 | 33 | 14 | 29 | 27 |
| –+- | futility | 0 | 43 | 53 | 52 | 43 |
| –+- | max_n | 0 | 0 | 0 | 0 | 0 |
| –+- | n | 12 (7, 17) | 6 (3, 12) | 8 (4, 14) | 6 (3, 11) | 6 (3, 12) |
| –+- | n_unique | 12 (7, 17) | 6 (3, 12) | 8 (4, 14) | 6 (3, 11) | 6 (3, 12) |
| –+- | post_p | NA (NA, NA) | 0.49 (0.2, 0.8) | 0.47 (0.2, 0.79) | 0.47 (0.21, 0.8) | 0.51 (0.22, 0.75) |
| –+- | rate | 0.021 (0.011, 0.035) | 0.023 (0.009, 0.048) | 0.022 (0.01, 0.043) | 0.023 (0.008, 0.048) | 0.021 (0.009, 0.047) |
| –++ | graduation | 0 | 41 | 24 | 36 | 29 |
| –++ | futility | 0 | 86 | 99 | 83 | 107 |
| –++ | max_n | 0 | 0 | 0 | 0 | 0 |
| –++ | n | 62 (50, 77) | 27 (11, 56) | 28 (11, 58) | 26 (11, 57) | 28 (12, 58) |
| –++ | n_unique | 62 (50, 77) | 27 (11, 56) | 28 (11, 58) | 26 (11, 57) | 28 (12, 58) |
| –++ | post_p | NA (NA, NA) | 0.44 (0.11, 0.83) | 0.46 (0.11, 0.86) | 0.47 (0.14, 0.86) | 0.46 (0.11, 0.86) |
| –++ | rate | 0.02 (0.016, 0.026) | 0.022 (0.016, 0.035) | 0.022 (0.015, 0.034) | 0.022 (0.015, 0.033) | 0.022 (0.016, 0.034) |
| -+– | graduation | 0 | 27 | 20 | 37 | 27 |
| -+– | futility | 0 | 76 | 92 | 63 | 91 |
| -+– | max_n | 0 | 0 | 0 | 0 | 0 |
| -+– | n | 78 (63, 97) | 35 (14, 68) | 34 (15, 72) | 34 (13, 68) | 34 (13, 64) |
| -+– | n_unique | 78 (63, 97) | 35 (14, 68) | 34 (15, 72) | 34 (13, 68) | 34 (13, 64) |
| -+– | post_p | NA (NA, NA) | 0.48 (0.11, 0.85) | 0.49 (0.12, 0.87) | 0.5 (0.13, 0.86) | 0.48 (0.11, 0.86) |
| -+– | rate | 0.021 (0.017, 0.025) | 0.022 (0.016, 0.032) | 0.022 (0.017, 0.033) | 0.021 (0.016, 0.031) | 0.022 (0.016, 0.033) |
| -+-+ | graduation | 0 | 35 | 29 | 46 | 30 |
| -+-+ | futility | 0 | 106 | 127 | 92 | 138 |
| -+-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+-+ | n | 52 (42, 65) | 21 (9, 49) | 24 (10, 50) | 23 (9, 47) | 23 (10, 47) |
| -+-+ | n_unique | 52 (42, 65) | 21 (9, 49) | 24 (10, 50) | 23 (9, 47) | 23 (10, 47) |
| -+-+ | post_p | NA (NA, NA) | 0.46 (0.11, 0.86) | 0.48 (0.13, 0.86) | 0.49 (0.11, 0.89) | 0.46 (0.11, 0.86) |
| -+-+ | rate | 0.02 (0.015, 0.026) | 0.022 (0.015, 0.038) | 0.022 (0.015, 0.034) | 0.021 (0.014, 0.035) | 0.023 (0.016, 0.034) |
| -++- | graduation | 0 | 42 | 24 | 46 | 34 |
| -++- | futility | 0 | 104 | 130 | 100 | 114 |
| -++- | max_n | 0 | 0 | 0 | 0 | 0 |
| -++- | n | 48 (36, 59) | 22 (8, 42) | 21 (10, 44) | 19 (8, 41) | 20 (8, 42) |
| -++- | n_unique | 48 (36, 59) | 22 (8, 42) | 21 (10, 44) | 19 (8, 41) | 20 (8, 42) |
| -++- | post_p | NA (NA, NA) | 0.5 (0.16, 0.86) | 0.46 (0.13, 0.85) | 0.5 (0.14, 0.87) | 0.51 (0.13, 0.87) |
| -++- | rate | 0.021 (0.016, 0.028) | 0.022 (0.015, 0.035) | 0.023 (0.016, 0.035) | 0.022 (0.014, 0.034) | 0.022 (0.014, 0.038) |
| -+++ | graduation | 0 | 49 | 32 | 53 | 36 |
| -+++ | futility | 0 | 133 | 156 | 121 | 156 |
| -+++ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+++ | n | 37 (27, 47) | 15 (6, 32) | 16 (7, 34) | 16 (6, 34) | 16 (8, 36) |
| -+++ | n_unique | 37 (27, 47) | 15 (6, 32) | 16 (7, 34) | 16 (6, 34) | 16 (8, 36) |
| -+++ | post_p | NA (NA, NA) | 0.47 (0.13, 0.84) | 0.44 (0.12, 0.84) | 0.49 (0.15, 0.86) | 0.45 (0.15, 0.85) |
| -+++ | rate | 0.02 (0.014, 0.027) | 0.022 (0.013, 0.04) | 0.023 (0.014, 0.039) | 0.022 (0.013, 0.038) | 0.022 (0.014, 0.034) |
| +— | graduation | 0 | 33 | 26 | 28 | 32 |
| +— | futility | 0 | 14 | 11 | 13 | 10 |
| +— | max_n | 0 | 0 | 0 | 0 | 0 |
| +— | n | 39 (30, 50) | 18 (7, 34) | 20 (9, 35) | 21 (10, 36) | 18 (8, 32) |
| +— | n_unique | 39 (30, 50) | 18 (7, 34) | 20 (9, 35) | 21 (10, 36) | 18 (8, 32) |
| +— | post_p | NA (NA, NA) | 0.49 (0.13, 0.85) | 0.5 (0.13, 0.86) | 0.5 (0.15, 0.84) | 0.48 (0.16, 0.84) |
| +— | rate | 0.021 (0.016, 0.029) | 0.022 (0.014, 0.038) | 0.022 (0.014, 0.034) | 0.022 (0.015, 0.033) | 0.022 (0.014, 0.036) |
| +–+ | graduation | 0 | 42 | 37 | 34 | 36 |
| +–+ | futility | 0 | 63 | 69 | 55 | 87 |
| +–+ | max_n | 0 | 0 | 0 | 0 | 0 |
| +–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +–+ | rate | 0.047 (0.047, 0.047) | 0 (0, 0) | 0.029 (0, 0.34) | 0 (0, 0.058) | 0.058 (0.058, 0.058) |
| +-+- | graduation | 0 | 49 | 29 | 40 | 39 |
| +-+- | futility | 0 | 47 | 58 | 59 | 48 |
| +-+- | max_n | 0 | 0 | 0 | 0 | 0 |
| +-+- | n | 27 (20, 36) | 13 (6, 25) | 13 (6, 24) | 15 (7, 25) | 13 (6, 24) |
| +-+- | n_unique | 27 (20, 36) | 13 (6, 25) | 13 (6, 24) | 15 (7, 25) | 13 (6, 24) |
| +-+- | post_p | NA (NA, NA) | 0.5 (0.18, 0.84) | 0.48 (0.17, 0.84) | 0.47 (0.15, 0.86) | 0.5 (0.15, 0.82) |
| +-+- | rate | 0.021 (0.014, 0.03) | 0.022 (0.012, 0.038) | 0.022 (0.012, 0.04) | 0.022 (0.014, 0.036) | 0.022 (0.013, 0.039) |
| +-++ | graduation | 0 | 57 | 39 | 46 | 41 |
| +-++ | futility | 0 | 90 | 102 | 88 | 112 |
| +-++ | max_n | 0 | 0 | 0 | 0 | 0 |
| +-++ | n | 6 (3, 10) | 3 (1, 7) | 3 (1, 7) | 4 (1, 7) | 4 (1, 7) |
| +-++ | n_unique | 6 (3, 10) | 3 (1, 7) | 3 (1, 7) | 4 (1, 7) | 4 (1, 7) |
| +-++ | post_p | NA (NA, NA) | 0.5 (0.29, 0.69) | 0.49 (0.3, 0.68) | 0.48 (0.32, 0.67) | 0.48 (0.31, 0.69) |
| +-++ | rate | 0.021 (0.004, 0.042) | 0.021 (0, 0.068) | 0.022 (0, 0.069) | 0.021 (0, 0.064) | 0.023 (0, 0.059) |
| ++– | graduation | 0 | 43 | 35 | 49 | 41 |
| ++– | futility | 0 | 80 | 95 | 68 | 94 |
| ++– | max_n | 0 | 0 | 0 | 0 | 0 |
| ++– | n | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| ++– | n_unique | 1 (0, 3) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) | 1 (0, 2) |
| ++– | post_p | NA (NA, NA) | 0.5 (0.43, 0.57) | 0.5 (0.43, 0.57) | 0.5 (0.43, 0.57) | 0.5 (0.44, 0.58) |
| ++– | rate | 0.016 (0, 0.107) | 0.019 (0, 0.11) | 0.017 (0, 0.096) | 0.02 (0, 0.105) | 0.016 (0, 0.096) |
| ++-+ | graduation | 0 | 51 | 44 | 55 | 44 |
| ++-+ | futility | 0 | 110 | 128 | 95 | 141 |
| ++-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++-+ | n | 8 (4, 12) | 4 (1, 9) | 4 (1, 9) | 5 (2, 9) | 5 (2, 9) |
| ++-+ | n_unique | 8 (4, 12) | 4 (1, 9) | 4 (1, 9) | 5 (2, 9) | 5 (2, 9) |
| ++-+ | post_p | NA (NA, NA) | 0.49 (0.28, 0.73) | 0.49 (0.29, 0.74) | 0.47 (0.28, 0.72) | 0.48 (0.27, 0.73) |
| ++-+ | rate | 0.02 (0.007, 0.037) | 0.022 (0, 0.055) | 0.021 (0.006, 0.061) | 0.023 (0.008, 0.062) | 0.022 (0.008, 0.057) |
| +++- | graduation | 0 | 58 | 38 | 57 | 46 |
| +++- | futility | 0 | 106 | 133 | 104 | 117 |
| +++- | max_n | 0 | 0 | 0 | 0 | 0 |
| +++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.44 (0.44, 0.44) |
| +++- | rate | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.021) | 0.05 (0.01, 0.059) |
| ++++ | graduation | 0 | 65 | 46 | 63 | 48 |
| ++++ | futility | 0 | 135 | 157 | 123 | 159 |
| ++++ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | post_p | NA (NA, NA) | 0.45 (0.45, 0.45) | 0.51 (0.5, 0.52) | 0.51 (0.43, 0.51) | 0.5 (0.5, 0.5) |
| ++++ | rate | 0 (0, 0.023) | 0.035 (0, 0.059) | 0.028 (0, 0.384) | 0.045 (0, 0.251) | 0 (0, 0.106) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities